| On the pathogenetic role of prostaglandins in Bartter's syndrome. | |
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MedLine Citation:
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PMID: 285569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two patients, one with Bartter's syndrome and one with severe abuse of diuretics, were investigated before and after indomethacin treatment. Before indomethacin the two patients showed a similar pattern of hypokalaemic alcalosis, secondary hyperaldosteronism, and increased urinary excretion of PGE2 and kallikrein. After a few days on peroral indomethacin medication the hypokalaemia was significantly improved, the plasma renin activity, and the urinary excretion of aldosterone, PGE2 and kallikrein were normalized in both patients. It is concluded that the beneficial effect of indomethacin cannot be used as a proof of prostaglandin overproduction as the primary defect in Bartter's syndrome. |
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Authors:
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I Nielsen; B Hesse; P Christensen |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta medica Scandinavica. Supplementum Volume: 625 ISSN: 0365-463X ISO Abbreviation: Acta Med. Scand. Suppl. Publication Date: 1979 |
Date Detail:
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Created Date: 1979-06-26 Completed Date: 1979-06-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370331 Medline TA: Acta Med Scand Suppl Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 135-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Aldosterone / urine Bartter Syndrome / drug therapy, metabolism* Female Humans Hyperaldosteronism / metabolism* Hypokalemia Indomethacin / therapeutic use Kallikreins / urine Middle Aged Prostaglandins / biosynthesis* Prostaglandins E / urine Renin / blood Triamterene / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 0/Prostaglandins E; 396-01-0/Triamterene; 52-39-1/Aldosterone; 53-86-1/Indomethacin; EC 3.4.21.-/Kallikreins; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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