| The pathogenesis of transfusion-related acute lung injury (TRALI). | |
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MedLine Citation:
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PMID: 17341264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In recent years, transfusion-related acute lung injury (TRALI) has developed from an almost unknown transfusion reaction to the most common cause of transfusion-related major morbidities and fatalities. A clinical definition of TRALI was established in 2004, based on acute respiratory distress, non-cardiogenic lung oedema temporal association with transfusion and hypoxaemia. Histological findings reveal lung oedema, capillary leucostasis and neutrophil extravasation. However, the pathogenesis of TRALI remains controversial. Leucocyte antibodies, present in fresh frozen plasma and platelet concentrates from multiparous donors, and neutrophil priming agents released in stored cellular blood components have been considered to be causative. As neutrophils and endothelial cells are pivotal in the pathogenesis of TRALI, a threshold model was established to try to unify the various reported findings on pathogenesis. This model comprises the priming of neutrophils and/or endothelium by the patient's co-morbidity, neutrophil and/or endothelial cell activation by the transfused blood component, and the severity of the TRALI reaction. |
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Authors:
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Jürgen Bux; Ulrich J H Sachs |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: British journal of haematology Volume: 136 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-07 Completed Date: 2007-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 788-99 Citation Subset: IM |
Affiliation:
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DRK-Blood Service West of the German Red Cross, Hagen, Germany. j.bux@bsdwest.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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complications Antibodies / blood Blood Component Transfusion / adverse effects Blood Transfusion / adverse effects* Humans Isoantibodies / blood Isoantigens / immunology Lung / blood supply Neutrophil Infiltration Neutrophils / immunology Pulmonary Edema / etiology*, immunology Respiratory Distress Syndrome, Adult / etiology*, immunology Syndrome Transplantation Immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Isoantibodies; 0/Isoantigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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