| The pathogenesis of infectious bursal disease: serologic, histopathologic, and clinical chemical observations. | |
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MedLine Citation:
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PMID: 6316894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infectious bursal disease in 35-day-old specific-pathogen-free (SPF) chickens was characterized clinically by its acute onset and brief duration. Clinical signs included depression, anorexia, diarrhea, and polyuria. A detectable precipitin antibody response occurred between 3 and 5 days postinoculation. Evaluation of pooled serum samples obtained from infectious bursal disease virus (IBDV)-infected chickens revealed transient changes in potassium, cholesterol, uric acid, lactate dehydrogenase, serum glutamic-oxalic transaminase, and serum proteins. Individual serum samples analyzed for uric acid concentration indicated that several IBDV-infected chickens had serum uric acid concentrations above the normal comparison range. Histopathologic examination of lymphoid and nonlymphoid tissues from IBDV-infected SPF chickens affirmed that the predominant lesion was lymphoid necrosis in the bursa of Fabricius. Other lymphoid organs were much less severely affected and possessed greater regenerative potential. Nonspecific and relatively mild changes were found in the liver and kidney: hepatic lipidosis and necrosis, renal intratubular crystalline deposits (probably urates), and increased ectopic lymphoid foci. There was no evidence of immune-complex-mediated arteritis/vasculitis in the sartorius muscle or any other tissue examined. Histopathologic and ultrastructural evidence of glomerulonephritis was rare but compatible with acute immune complexemia. |
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Authors:
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D H Ley; R Yamamoto; A A Bickford |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Avian diseases Volume: 27 ISSN: 0005-2086 ISO Abbreviation: Avian Dis. Publication Date: 1983 Oct-Dec |
Date Detail:
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Created Date: 1984-01-27 Completed Date: 1984-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370617 Medline TA: Avian Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1060-85 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Viral / biosynthesis* Bursa of Fabricius / pathology Chickens* Female Fluorescent Antibody Technique Infectious bursal disease virus / immunology* Kidney / pathology Liver / pathology Male Microscopy, Electron Poultry Diseases / etiology*, immunology, pathology Precipitin Tests / veterinary Reoviridae / immunology* Retroviridae Infections / immunology, pathology, veterinary* Specific Pathogen-Free Organisms Spleen / pathology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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