Document Detail

The pathogenesis of infectious bursal disease: serologic, histopathologic, and clinical chemical observations.
MedLine Citation:
PMID:  6316894     Owner:  NLM     Status:  MEDLINE    
Infectious bursal disease in 35-day-old specific-pathogen-free (SPF) chickens was characterized clinically by its acute onset and brief duration. Clinical signs included depression, anorexia, diarrhea, and polyuria. A detectable precipitin antibody response occurred between 3 and 5 days postinoculation. Evaluation of pooled serum samples obtained from infectious bursal disease virus (IBDV)-infected chickens revealed transient changes in potassium, cholesterol, uric acid, lactate dehydrogenase, serum glutamic-oxalic transaminase, and serum proteins. Individual serum samples analyzed for uric acid concentration indicated that several IBDV-infected chickens had serum uric acid concentrations above the normal comparison range. Histopathologic examination of lymphoid and nonlymphoid tissues from IBDV-infected SPF chickens affirmed that the predominant lesion was lymphoid necrosis in the bursa of Fabricius. Other lymphoid organs were much less severely affected and possessed greater regenerative potential. Nonspecific and relatively mild changes were found in the liver and kidney: hepatic lipidosis and necrosis, renal intratubular crystalline deposits (probably urates), and increased ectopic lymphoid foci. There was no evidence of immune-complex-mediated arteritis/vasculitis in the sartorius muscle or any other tissue examined. Histopathologic and ultrastructural evidence of glomerulonephritis was rare but compatible with acute immune complexemia.
D H Ley; R Yamamoto; A A Bickford
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Avian diseases     Volume:  27     ISSN:  0005-2086     ISO Abbreviation:  Avian Dis.     Publication Date:    1983 Oct-Dec
Date Detail:
Created Date:  1984-01-27     Completed Date:  1984-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370617     Medline TA:  Avian Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1060-85     Citation Subset:  IM    
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MeSH Terms
Antibodies, Viral / biosynthesis*
Bursa of Fabricius / pathology
Fluorescent Antibody Technique
Infectious bursal disease virus / immunology*
Kidney / pathology
Liver / pathology
Microscopy, Electron
Poultry Diseases / etiology*,  immunology,  pathology
Precipitin Tests / veterinary
Reoviridae / immunology*
Retroviridae Infections / immunology,  pathology,  veterinary*
Specific Pathogen-Free Organisms
Spleen / pathology
Time Factors
Reg. No./Substance:
0/Antibodies, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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