Document Detail

The pathogenesis of idiopathic scoliosis: uncoupled neuro-osseous growth?
MedLine Citation:
PMID:  11806387     Owner:  NLM     Status:  MEDLINE    
This paper examines the following speculative hypothesis: "that in some patients with scoliosis there is disproportionate neuro-osseous growth--the longitudinal growth of the spinal cord fails to keep pace with the growth of the vertebral column and, as a consequence, the spine buckles into a scoliosis deformity". A literature review of the morphology and neurology of scoliosis does not deny the hypothesis. Several mechanisms are suggested as to why the spinal cord growth could become uncoupled from osseous growth.
R W Porter
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society     Volume:  10     ISSN:  0940-6719     ISO Abbreviation:  Eur Spine J     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-24     Completed Date:  2002-05-07     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  9301980     Medline TA:  Eur Spine J     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  473-81     Citation Subset:  IM    
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MeSH Terms
Elastin / physiology
Free Radicals
Growth Substances
Scoliosis / etiology*,  pathology
Spinal Cord / growth & development,  pathology
Spine / growth & development,  pathology
Reg. No./Substance:
0/Calmodulin; 0/Free Radicals; 0/Growth Substances; 73-31-4/Melatonin; 9007-58-3/Elastin
Comment In:
Eur Spine J. 2001 Dec;10(6):488-9   [PMID:  15614984 ]
Eur Spine J. 2001 Dec;10(6):482-7   [PMID:  15614983 ]

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