Document Detail


The pathogenesis of dengue.
MedLine Citation:
PMID:  23449140     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Dengue is one of the most rapidly spreading vector-borne diseases in the world, with the incidence increasing 30-fold in the past 50 years. There are currently no licensed treatments or vaccines for dengue. This review covers the recent advances in our understanding of dengue pathogenesis, including host and viral determinants.
RECENT FINDINGS: The pathogenesis of severe dengue is thought to be immune-mediated due to the timing of the clinical manifestations and higher incidence in secondary infections with a heterologous serotype. Recent evidence has provided further information of neutralizing versus enhancing monoclonal antibodies and their target epitopes on the dengue virion, which has major implications for vaccine design. The role of T-cell immunopathology has also been advanced with recent evidence of cross-reactive high pro-inflammatory cytokine producing T cells predominating in severe dengue. Recent large genome-wide association studies have identified specific susceptibility loci associated with severe disease. Epidemiological studies have served to define certain at-risk groups and specific viral virulence factors have recently been described.
SUMMARY: The pathogenesis of dengue is likely to be a complex interplay of host immunity and genetic predisposition combined with certain viral virulence factors. Better understanding of the underlying mechanisms leading to severe dengue is crucial if we are to develop prognostic markers, novel diagnostics and therapeutics and ultimately a balanced and safe vaccine.
Authors:
Sophie Yacoub; Juthathip Mongkolsapaya; Gavin Screaton
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  26     ISSN:  1473-6527     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-23     Completed Date:  2013-09-26     Revised Date:  2014-07-15    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  284-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Dengue* / genetics,  immunology
Dengue Virus / genetics,  pathogenicity*
Genetic Predisposition to Disease
Host-Parasite Interactions / genetics,  immunology
Humans
Immunity, Cellular / physiology
Immunity, Humoral / physiology
T-Lymphocytes / immunology
Virulence Factors
Grant Support
ID/Acronym/Agency:
089276//Wellcome Trust; 095541//Wellcome Trust
Chemical
Reg. No./Substance:
0/Virulence Factors

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