Document Detail

The pathogenesis of DOCA-salt hypertension.
MedLine Citation:
PMID:  1498343     Owner:  NLM     Status:  MEDLINE    
Deoxycorticosterone acetate (DOCA) is an agent commonly used to induce hypertension in experimental animals. This form of hypertension is dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system. Additionally, there are characteristic changes involving the cardiovascular system and baroreflex responses. This review will discuss aspects of the pathogenesis of DOCA hypertension and the effect of various antihypertensive agents on the development of this form of hypertension.
J Schenk; J H McNeill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of pharmacological and toxicological methods     Volume:  27     ISSN:  1056-8719     ISO Abbreviation:  J Pharmacol Toxicol Methods     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-09-17     Completed Date:  1992-09-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9206091     Medline TA:  J Pharmacol Toxicol Methods     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-70     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Antihypertensive Agents / pharmacology,  therapeutic use*
Blood Pressure / drug effects
Desoxycorticosterone / administration & dosage,  pharmacology*
Disease Models, Animal
Hemodynamics / drug effects
Hypertension / chemically induced*,  drug therapy,  physiopathology
Pressoreceptors / physiology
Renin-Angiotensin System / physiology
Sodium Chloride
Reg. No./Substance:
0/Antihypertensive Agents; 64-85-7/Desoxycorticosterone; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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