Document Detail


The pathogenesis of Chiari I malformation and syringomyelia.
MedLine Citation:
PMID:  21513643     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
METHODS: A literature review for articles pertaining to Chiari I malformation or syringomyelia before August 2010 was conducted; in addition, the author's own experience in treating Chiari I malformation and syringomyelia is included.
RESULTS: Chiari I malformation has been defined radiographically as cerebellar tonsillar herniation or ectopia 5 mm or greater below the foramen magnum. By this narrow definition, Chiari I malformation (i.e. cerebellar tonsillar herniation or ectopia 5 mm or greater below the foramen magnum) likely encompasses a heterogeneous grouping of disorders caused by different mechanisms. Molecular and genetic studies have been helpful in furthering our understanding of Chiari I malformation.
CONCLUSION: A review of the pathogeneses of Chiari I malformation and syringomyelia is reported.
Authors:
Raymond F Sekula; Gregory D Arnone; Christine Crocker; Khaled M Aziz; Noam Alperin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  33     ISSN:  1743-1328     ISO Abbreviation:  Neurol. Res.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  232-9     Citation Subset:  IM    
Affiliation:
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
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