Document Detail

The path for metal complexes to a DNA target.
MedLine Citation:
PMID:  23423158     Owner:  NLM     Status:  MEDLINE    
The discovery of cisplatin as a therapeutic agent stimulated a new era in the application of transition metal complexes for therapeutic design. Here we describe recent results on a variety of transition metal complexes targeted to DNA to illustrate many of the issues involved in new therapeutic design. We describe first structural studies of complexes bound covalently and non-covalently to DNA to identify potential lesions within the cell. We then review the biological fates of these complexes, illustrating the key elements in obtaining potent activity, the importance of uptake and subcellular localization of the complexes, as well as the techniques used to delineate these characteristics. Genomic DNA provides a challenging but valuable target for new transition metal-based therapeutics.
Alexis C Komor; Jacqueline K Barton
Related Documents :
24145408 - Critical clamp loader processing by an essential aaa+ protease in caulobacter crescentus.
23073078 - Molecular recognition between dna and a copper-based anticancer complex.
10986298 - Infrequency of detection of particle-associated msrv/herv-w rna in the synovial fluid o...
22767528 - Systematic studies of uv stability and photopolymerization efficiency of dna-based nano...
7537368 - Single strand targeted triplex-formation. destabilization of guanine quadruplex structu...
2822548 - Copper-catalyzed dna damage by ascorbate and hydrogen peroxide: kinetics and yield.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  49     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-05     Completed Date:  2013-09-23     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  3617-30     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Transport
Coordination Complexes / chemistry,  pharmacology*
DNA / chemistry,  metabolism*
Grant Support
Reg. No./Substance:
0/Coordination Complexes; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Specific recognition of cytosine by hypoxanthine in pyrrolidinyl peptide nucleic acid.
Next Document:  PDGF supplementation alters oxidative events in wound healing process: a time course study.