Document Detail


The path for metal complexes to a DNA target.
MedLine Citation:
PMID:  23423158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery of cisplatin as a therapeutic agent stimulated a new era in the application of transition metal complexes for therapeutic design. Here we describe recent results on a variety of transition metal complexes targeted to DNA to illustrate many of the issues involved in new therapeutic design. We describe first structural studies of complexes bound covalently and non-covalently to DNA to identify potential lesions within the cell. We then review the biological fates of these complexes, illustrating the key elements in obtaining potent activity, the importance of uptake and subcellular localization of the complexes, as well as the techniques used to delineate these characteristics. Genomic DNA provides a challenging but valuable target for new transition metal-based therapeutics.
Authors:
Alexis C Komor; Jacqueline K Barton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  49     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-05     Completed Date:  2013-09-23     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  3617-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Transport
Coordination Complexes / chemistry,  pharmacology*
DNA / chemistry,  metabolism*
Humans
Grant Support
ID/Acronym/Agency:
GM33309/GM/NIGMS NIH HHS; R01 GM033309/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Coordination Complexes; 9007-49-2/DNA
Comments/Corrections

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