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The past, present and future of renin-angiotensin aldosterone system inhibition.
MedLine Citation:
PMID:  23121914     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The renin-angiotensin aldosterone system (RAAS) is central to the pathogenesis of cardiovascular disease. RAAS inhibition can reduce blood pressure, prevent target organ damage in hypertension and diabetes, and improve outcomes in patients with heart failure and/or myocardial infarction. This review presents the history of RAAS inhibition including a summary of key heart failure, myocardial infarction, hypertension and atrial fibrillation trials. Recent developments in RAAS inhibition are discussed including implementation and optimization of current drug therapies. Finally, ongoing clinical trials, opportunities for future trials and issues related to the barriers and approvability of novel RAAS inhibitors are highlighted.
Authors:
Robert J Mentz; George L Bakris; Bernard Waeber; John J V McMurray; Mihai Gheorghiade; Luis M Ruilope; Aldo P Maggioni; Karl Swedberg; Ileana L Piña; Mona Fiuzat; Christopher M O'Connor; Faiez Zannad; Bertram Pitt
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-30
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Duke University Medical Center, Durham, NC, USA. Electronic address: robert.mentz@duke.edu.
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