Document Detail

The partition of cis-parinaric acid and trans-parinaric acid among aqueous, fluid lipid, and solid lipid phases.
MedLine Citation:
PMID:  7007869     Owner:  NLM     Status:  MEDLINE    
In this article, I review the current information concerning the partition of the fluorescent probes, cis-parinaric acid (9, 11, 13, 15-cis, trans, trans, cis-octadecatetraenoic acid) and trans-parinaric acid (9, 11, 13, 15-all trans-octadecatetraenoic acid) among aqueous, solid lipid, and fluid lipid phases. The association of these probes with lipid is described by a mole fraction partition coefficient whose value is trypically in the range of 1-5 x 10(6), a reasonable value in light of partition coefficients for other fatty acids between hydrophobic phases and water. The partition coefficient, in the absence of lipid phase changes, is relatively independent of temperature and only slightly dependent on the total aqueous probe concentration. In lipid samples which contain coexisting fluid and solid phases, trans-parinaric acid preferentially partitions into the solid phase, while cis-parinaric acid distributes nearly equally between fluid and solid phases. This partition behavior probably arises from the molecular shape of the cis and trans parinaric acid in mixed lipid systems or membranes it is possible to evaluate the proportion of lipid components involved in phase changes or phase separation. From fluorescence energy transfer between protein typtophan residues and the parinaric acid isomers it is possible to gain information about the organization of lipids and proteins in membranes and model systems. I close the review by considering some of the membrane research areas where these probes and their various lipid derivatives may be particularly useful.
L A Sklar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  32     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  169-77     Citation Subset:  IM    
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MeSH Terms
Chemistry, Physical
Fatty Acids, Unsaturated*
Fluorescence Polarization
Fluorescent Dyes*
Membrane Lipids
Physicochemical Phenomena
Surface Properties
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Fluorescent Dyes; 0/Lipids; 0/Membrane Lipids; 18427-44-6/parinaric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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