| A particulate pulse-release system and mathematical description with the Maxwell-Stefan theory. | |
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MedLine Citation:
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PMID: 10742588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this contribution both the development of a multi-particulate delayed release system with release properties dependent on the swelling of an UV crosslinked coating and a mathematical model to describe its release properties are presented. The formulation consists of a water-soluble core coated with a copolymer of methacrylic acid and ethyl acrylate. Incorporating a network of crosslinked pentaerythritol triacrylate decreases the water-solubility of the coating. After immersing the formulation in water the coating will take up water and subsequently swell in such a degree that the diffusion coefficient of water in the coating will increase. This makes the coating permeable to the dissolved components present in the core. The swelling kinetics of the coating are such that the formulation has a pulse-release profile, i.e. a fast release of the contents is obtained after a pre-determined lag-time. Both the coating thickness and the duration of the UV crosslinking time can be used to adjust the lag-time. The experimental results are used to estimate the Maxwell-Stefan diffusion coefficients of water in the coating. The relation between the Maxwell-Stefan diffusion coefficient and the mole fraction of water in the coating differs from results found in the literature. However, the prediction of the release time based on the presented model is in good agreement with the experimental findings. |
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Authors:
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P J Hartman Kok; P Vonk; N W Kossen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of controlled release : official journal of the Controlled Release Society Volume: 66 ISSN: 0168-3659 ISO Abbreviation: J Control Release Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-08-02 Completed Date: 2000-08-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607908 Medline TA: J Control Release Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 293-306 Citation Subset: IM |
Affiliation:
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Department of Industrial Pharmacy, University of Groningen, 9713 AV, Groningen, The Netherlands. P.J.A.Hartman.Kok@farm.rug.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrylates Delayed-Action Preparations* Diffusion Methacrylates Microscopy, Electron, Scanning Microspheres Models, Theoretical* Patents as Topic Pulsatile Flow* |
| Chemical | |
Reg. No./Substance:
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0/Acrylates; 0/Delayed-Action Preparations; 0/Methacrylates; 140-88-5/ethyl acrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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