| The particular traits of carcinogenesis induced in Wistar rats by aflatoxin B1. IV. Porphyrins and the activity of gamma-glutamyltranspeptidase in Wistar rats bearing transplantable hepatoma. | |
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MedLine Citation:
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PMID: 6131386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In inbred Wistar rats bearing transplantable hepatoma induced by aflatoxin B1 tissue porphyrins and the level of the serum gamma-glutamyltranspeptidase (GGTP) were studied. A liver reaction in carriers of transplants was ascertained, that was expressed especially by an increase in porphyrins, mainly the protoporphyrin fraction, and by morphological changes. The content of porphyrins in lung metastases was higher than in hepatomas and livers. The level of serum GGTP was higher in females up to the 40th passage, and up to the 90th passage higher in males. Hormonal conditioning of the early AFB1-hepatoma passages is supported by a lower level of serum GGTP in females and higher in males, and the liver and tumor porphyrins in animals previously castrated in comparison with uncastrated rats. Comparative data of the quantity and quality of porphyrins in different rat tissues with primary and transplantable AFB1-hepatomas demonstrate that systemic metabolic disorders of porphyrins are greater in rats with primary than in the case of transplantable tumors. |
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Authors:
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B Zawirska |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neoplasma Volume: 29 ISSN: 0028-2685 ISO Abbreviation: Neoplasma Publication Date: 1982 |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0377266 Medline TA: Neoplasma Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 693-707 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxin B1 Aflatoxins / toxicity* Animals Castration Female Kidney / analysis Liver / analysis Liver Neoplasms, Experimental / analysis*, chemically induced, pathology Male Neoplasm Transplantation Porphyrins / analysis* Rats Rats, Inbred Strains Sex Factors gamma-Glutamyltransferase / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins; 0/Porphyrins; 1162-65-8/Aflatoxin B1; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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