Document Detail

The participation of mediator and peptidergic systems of the brain in conditioned reflex mechanisms.
MedLine Citation:
PMID:  1703645     Owner:  NLM     Status:  MEDLINE    
New data on the significance of mediator and peptidergic systems of the striatal level in the organization of alimentary conditioned reflexes are presented in this report. The role of acetylcholine-, dopamine-, GABA-and P-ergic systems of the caudate nucleus and the amygdala in the realization of positive and negative conditioned reflexes was investigated. The experiments were carried out on dogs with chemotrodes and microelectrodes implanted in subcortical structures. The results of the experiments with microinjections of the relevant substances into individual subcortical structures showed that activation of the same mediator system in various structures may lead to both unidirectional and multidirectional behavioral effects. On the other hand, the activation of various subcortical mediator systems can lead to identical changes in conditioned reflex activity. The effect of the administration of activators or blockers of a subcortical mediator system depends in many ways on the functional state of the nervous system at the moment of administration and on the localization of the microinjection. It is difficult to predict beforehand the role of various subcortical structures in the organization of integrated behavioral acts. The question of the necessity of studying mediator and peptidergic systems of each subcortical structure in order to understand their significance in the mechanisms of the conditioned reflex is raised.
N F Suvorov; N L Voilokova; S I Shefer; A F Yakimovskii; V T Shuvaev
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience and behavioral physiology     Volume:  20     ISSN:  0097-0549     ISO Abbreviation:  Neurosci. Behav. Physiol.     Publication Date:    1990 Jul-Aug
Date Detail:
Created Date:  1991-03-05     Completed Date:  1991-03-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0330471     Medline TA:  Neurosci Behav Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-70     Citation Subset:  IM    
I.P. Pavlov Institute of Physiology, Academy of Sciences, USSR [AN SSSR], Leningrad.
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MeSH Terms
Acetylcholine / physiology
Amygdala / physiology
Brain / physiology*
Caudate Nucleus / physiology
Conditioning, Classical / physiology*
Enkephalin, Leucine / administration & dosage,  pharmacology
Peptides / physiology*
Picrotoxin / pharmacology
Receptors, Cholinergic / drug effects,  physiology
Substance P / pharmacology
gamma-Aminobutyric Acid / physiology
Reg. No./Substance:
0/Peptides; 0/Receptors, Cholinergic; 124-87-8/Picrotoxin; 33507-63-0/Substance P; 51-84-3/Acetylcholine; 56-12-2/gamma-Aminobutyric Acid; 58822-25-6/Enkephalin, Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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