| A partial characterization of uterine and mammary growth stimulatory activity from placenta. | |
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MedLine Citation:
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PMID: 3139577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both placenta and prolactin are required for maintenance of gestation in rabbit. This study was undertaken to characterize the influence of placenta on uterus and mammary gland using the virgin pseudopregnant rabbit as a model system. Homogenates of 20-day rabbit placenta were found to stimulate increased growth of uterine and mammary tissue in pseudopregnant rabbits. Essentially, all of this uterine growth occurred in endometrium and represented growth of both stromal and epithelial cell types. After fractionation by successive extraction of rabbit placenta with acetone and bicarbonate, both extracts were found to stimulate uterine and mammary growth in pseudo-pregnant rabbits when measured on day 20 of pseudopregnancy after 13 days of treatment at extract doses equivalent to that found in 0.1 gram of placenta. Approximately 75% of this stimulatory activity is found in the acetone extract and the remainder appears in the aqueous extract. The extracts stimulate a maximum 90% increase in uterine growth and 400% increase in mammary pad area. Both activities exhibit logarithmic response characteristics, yet significant changes in serum 17 beta estradiol, progesterone, 20 alpha dihydroxyprogesterone and prolactin did not occur. These observations suggest the presence of an unidentified factor in rabbit placenta which has a non-ovarian mediated stimulatory activity on endometrial and mammary growth. |
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Authors:
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F E Grissom; C L Brooks |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Growth, development, and aging : GDA Volume: 52 ISSN: 1041-1232 ISO Abbreviation: Growth Dev Aging Publication Date: 1988 |
Date Detail:
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Created Date: 1988-11-08 Completed Date: 1988-11-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8809704 Medline TA: Growth Dev Aging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 23-35 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algestone
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blood Animals Endometrium / growth & development Estradiol / blood Female Mammary Glands, Animal / growth & development* Placenta / physiology* Placental Extracts / pharmacology Progesterone / blood Pseudopregnancy Rabbits Uterus / growth & development* |
| Grant Support | |
ID/Acronym/Agency:
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5HT32GM07800/GM/NIGMS NIH HHS; HD15889/HD/NICHD NIH HHS; RR08016/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Placental Extracts; 50-28-2/Estradiol; 57-83-0/Progesterone; 595-77-7/Algestone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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