Document Detail


The parasympathetic neuroeffector junction of the heart.
MedLine Citation:
PMID:  2408285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review has directed attention to the anatomical, biochemical, physiological, and pharmacological features of cardiac parasympathetic neuroeffector transmission. The relationships among these properties have permitted a synthesis of the operation of the parasympathetic nervous system at the subcellular, cellular, tissue, and organ level in the heart. However, the attempt to obtain a comprehensive model of parasympathetic neuroeffector transmission in the heart has not only unmasked many features of junctional activity that are poorly understood, but also indicated significant gaps between in vitro and in vivo experimental situations.
Authors:
K Löffelholz; A J Pappano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Pharmacological reviews     Volume:  37     ISSN:  0031-6997     ISO Abbreviation:  Pharmacol. Rev.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-07-17     Completed Date:  1985-07-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0421737     Medline TA:  Pharmacol Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / metabolism
Animals
Electrophysiology
Heart / drug effects,  innervation*
Heart Rate / drug effects
Humans
Ion Channels / drug effects
Myocardial Contraction / drug effects
Myocardium / metabolism
Neuroeffector Junction / physiology*
Neurons / physiology
Parasympathetic Nervous System / physiology*
Parasympathomimetics / pharmacology
Potassium / physiology
Receptors, Muscarinic / drug effects
Synaptic Transmission
Time Factors
Vagus Nerve / physiology
Grant Support
ID/Acronym/Agency:
HL-13339/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Ion Channels; 0/Parasympathomimetics; 0/Receptors, Muscarinic; 51-84-3/Acetylcholine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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