| The parasympathetic neuroeffector junction of the heart. | |
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MedLine Citation:
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PMID: 2408285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review has directed attention to the anatomical, biochemical, physiological, and pharmacological features of cardiac parasympathetic neuroeffector transmission. The relationships among these properties have permitted a synthesis of the operation of the parasympathetic nervous system at the subcellular, cellular, tissue, and organ level in the heart. However, the attempt to obtain a comprehensive model of parasympathetic neuroeffector transmission in the heart has not only unmasked many features of junctional activity that are poorly understood, but also indicated significant gaps between in vitro and in vivo experimental situations. |
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Authors:
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K Löffelholz; A J Pappano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Pharmacological reviews Volume: 37 ISSN: 0031-6997 ISO Abbreviation: Pharmacol. Rev. Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-07-17 Completed Date: 1985-07-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0421737 Medline TA: Pharmacol Rev Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1-24 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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metabolism Animals Electrophysiology Heart / drug effects, innervation* Heart Rate / drug effects Humans Ion Channels / drug effects Myocardial Contraction / drug effects Myocardium / metabolism Neuroeffector Junction / physiology* Neurons / physiology Parasympathetic Nervous System / physiology* Parasympathomimetics / pharmacology Potassium / physiology Receptors, Muscarinic / drug effects Synaptic Transmission Time Factors Vagus Nerve / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-13339/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 0/Parasympathomimetics; 0/Receptors, Muscarinic; 51-84-3/Acetylcholine; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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