| The parasympathetic nervous system in the quest for stroke therapeutics. | |
| | |
MedLine Citation:
|
PMID: 21364605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Stroke is a devastating neurovascular disease with limited therapeutic options. The pathogenesis of stroke involves complex interrelated molecular mechanisms including excitotoxicity, oxidative and nitrosative stress, cortical spreading depolarizations, inflammation, necrosis, and apoptosis. Successful development of stroke therapeutics depends on understanding these molecular mechanisms and how to counteract them to limit tissue damage during stroke. Activation of the parasympathetic nervous system (PNS) has been shown to antagonize a multiplicity of pathologic mechanisms. Elements of parasympathetic activation such as vagus nerve stimulation have already been used successfully in treating brain disorders such as epilepsy and depression. This review discusses the anatomical basis and molecular mechanisms involved in activation of the PNS, and assesses the strength of available evidence for the further development of this modality into a stroke therapy. |
| | |
Authors:
|
Cletus Cheyuo; Asha Jacob; Rongqian Wu; Mian Zhou; Gene F Coppa; Ping Wang |
Related Documents
:
|
12659865 - 3c8 antigen is a novel protein expressed by human follicular dendritic cells. 9349525 - Molecular characterization and differential gene induction of the neuroendocrine-specif... 6452475 - Direct in vitro evidence for different susceptibilities to 4-hydroperoxycyclophosphamid... 10938745 - Suppression of the humoral immune response of atlantic salmon, salmo salar l. by the 64... 21289335 - Ionizing radiation affects epidermal growth factor receptor signalling and metalloprote... 9044435 - Characterization of leukotriene production in vivo and in vitro in resident and elicite... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-03-02 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 31 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-02 Completed Date: 2011-06-28 Revised Date: 2012-05-01 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 1187-95 Citation Subset: IM |
Affiliation:
|
Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Humans Parasympathetic Nervous System / physiology* Stroke / physiopathology*, therapy* Vagus Nerve / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
R01 AG028352/AG/NIA NIH HHS; R01 GM053008/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traum...
Next Document: Higher vitamin D intake is needed to achieve serum 25(OH)D levels greater than 50?nmol/l in Québec ...