Document Detail


The parasitic cell wall of Coccidioides immitis.
MedLine Citation:
PMID:  11800267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coccidioides immitis is a human respiratory pathogen characterized by a parasitic cycle that is unique among fungi that cause systemic mycoses. Biochemical, molecular and immunological studies of the cell wall of C. immitis have focused on three distinct events of parasitic cell differentiation: isotropic growth, segmentation and endosporulation. Current investigations of each developmental phase in vitro include the identification, expression analysis, and disruption of synthase and hydrolase genes that are suspected to have key roles in morphogenesis. Temporal expression of families of beta-glucosidase and chitinase genes are of particular interest because their products may participate in wall modification during both isotropic growth and endosporulation and, thereby, represent potential molecular targets for novel antifungal drugs. Furthermore, our immunological studies of these and other isolated parasitic cell-wall components have resulted in the identification of antigens with demonstrated impact on host response to coccidioidal infection. C. immitis has proved to be an excellent model for fungal cell-wall research.
Authors:
G T Cole; C Y Hung
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Medical mycology     Volume:  39 Suppl 1     ISSN:  1369-3786     ISO Abbreviation:  Med. Mycol.     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-21     Completed Date:  2002-06-18     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  31-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Cell Wall / chemistry*,  metabolism
Chitin Synthase / genetics
Chitinase / genetics
Coccidioides / chemistry*,  growth & development,  metabolism
Glucosyltransferases / genetics
Molecular Sequence Data
beta-Glucosidase / genetics
Grant Support
ID/Acronym/Agency:
AI19149/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
EC 2.4.1.-/Glucosyltransferases; EC 2.4.1.-/glucan synthase; EC 2.4.1.16/Chitin Synthase; EC 3.2.1.14/Chitinase; EC 3.2.1.21/beta-Glucosidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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