| On the parametrization of the toxicity of organic chemicals to Tetrahymena pyriformis. The problem of establishing a uniform activity. | |
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MedLine Citation:
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PMID: 12132897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this report we illustrate the importance of making an effort to ensure that all of the dependent variables in a QSAR are associated with one mechanism of action. If this cannot be established, it will not be possible to compare the QSAR with others acting on different biological systems. That is, such information cannot be used to develop a science of chemical-biological interactions. A study of the action of a large set of phenols acting on Tetrahymena pyriformis made by Cronin and Schultz is analyzed to illustrate the problem. |
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Authors:
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Suresh Babu Mekapati; Corwin Hansch |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of chemical information and computer sciences Volume: 42 ISSN: 0095-2338 ISO Abbreviation: J Chem Inf Comput Sci Publication Date: 2002 Jul-Aug |
Date Detail:
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Created Date: 2002-07-22 Completed Date: 2002-09-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7505012 Medline TA: J Chem Inf Comput Sci Country: United States |
Other Details:
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Languages: eng Pagination: 956-61 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Pomona College, Claremont, California 91711, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Computer Simulation* Phenols / chemistry*, toxicity* Quantitative Structure-Activity Relationship Tetrahymena pyriformis / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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R01 ES 07595/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phenols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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