| The paralogous salivary anti-complement proteins IRAC I and IRAC II encoded by Ixodes ricinus ticks have broad and complementary inhibitory activities against the complement of different host species. | |
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MedLine Citation:
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PMID: 17223370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several observations suggest that inhibition of the host complement alternative pathway by Ixodes tick saliva is crucial to achieve blood feeding. We recently described two paralogous anti-complement proteins called Ixodes ricinus anti-complement (IRAC) proteins I and II co-expressed in I. ricinus salivary glands. Phylogenetic analyses suggested that these sequences were diversifying by a process of positive Darwinian selection, possibly leading to molecules with different biological properties. In the present study, we tested the hypothesis that each paralogue may have different inhibitory activities against the complement of different natural host species, thereby contributing to broaden the host range of I. ricinus ticks. IRAC I and IRAC II were tested against the complement of eight I. ricinus natural host species (six mammals and two birds). The results demonstrate that IRAC I and IRAC II have broad and complementary inhibition activities against the complement of different host species. This report is the first description of paralogous anti-complement molecules encoded by a pathogen with broad and complementary inhibitory activities against the complement of different host species. |
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Authors:
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Hélène Schroeder; Virginie Daix; Laurent Gillet; Jean-Christophe Renauld; Alain Vanderplasschen |
Publication Detail:
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Type: Letter Date: 2006-12-11 |
Journal Detail:
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Title: Microbes and infection / Institut Pasteur Volume: 9 ISSN: 1286-4579 ISO Abbreviation: Microbes Infect. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-16 Completed Date: 2007-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883508 Medline TA: Microbes Infect Country: France |
Other Details:
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Languages: eng Pagination: 247-50 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Birds Complement Inactivator Proteins / metabolism* Complement Pathway, Alternative* Complement System Proteins / immunology* Humans Ixodes / metabolism*, pathogenicity Mammals Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Complement Inactivator Proteins; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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