Document Detail

Is parainfluenza virus a threatening virus for human cancer cell lines?
MedLine Citation:
PMID:  19624309     Owner:  NLM     Status:  MEDLINE    
Immortalized cell lines, such as human cancer cell lines, are an indispensable experimental resource for many types of biological and medical research. However, unless the cell line has been authenticated prior to use, interpretation of experimental results may be problematic. The potential problems this may cause are illustrated by studies in which authentication of cell lines has not been carried out. For example, immortalized cell lines may unknowingly be infected with viruses that alter their characteristics. In fact, parainfluenza virus type 5 (PIV5) poses a threat to the use of immortalized cell lines in biological and medical research; PIV5 infection significantly alters cellular physiology associated with the response to interferon. If PIV5 infection is widespread in immortalized cell lines, then a very large number of published studies might have to be re-evaluated. Fortunately, analyses of a large number of immortalized cell lines indicate that PIV5 infection is not widespread.
Inaho Danjoh; Hiyori Sone; Nahomi Noda; Emi Iimura; Mariko Nagayoshi; Kaoru Saijo; Takashi Hiroyama; Yukio Nakamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-23
Journal Detail:
Title:  Human cell     Volume:  22     ISSN:  1749-0774     ISO Abbreviation:  Hum. Cell     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-23     Completed Date:  2009-09-03     Revised Date:  2012-05-31    
Medline Journal Info:
Nlm Unique ID:  8912329     Medline TA:  Hum Cell     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  81-4     Citation Subset:  IM    
RIKEN BioResource Center, Ibaraki, Japan.
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MeSH Terms
Blotting, Western
Cell Line, Tumor / virology*
Rubulavirus / genetics,  isolation & purification,  pathogenicity*
STAT1 Transcription Factor / metabolism
Tissue Banks
Viral Proteins / physiology
Reg. No./Substance:
0/STAT1 Transcription Factor; 0/V protein, Paramyxovirus; 0/Viral Proteins

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