Document Detail


The paradoxical functions of B cells and antibodies in transplantation.
MedLine Citation:
PMID:  23335803     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Scarcely anyone would dispute that donor-specific B cells and the Abs that they produce can cause rejection of transplants. Less clear and more controversial, however, is the possibility that donor-specific B cells and the Abs that they produce are one or more means by which transplants can be protected from injury. In this article, we review and discuss this possibility and consider how less well-known functions of B cells and Abs might impact on the design of therapeutics and the management of transplant recipients.
Authors:
Marilia I Cascalho; Brian J Chen; Mandy Kain; Jeffrey L Platt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  190     ISSN:  1550-6606     ISO Abbreviation:  J. Immunol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-03-26     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  875-9     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen Presentation
B-Lymphocytes / immunology*
Cellular Microenvironment
Histocompatibility Antigens / immunology
Humans
Immunity, Cellular
Isoantibodies / immunology
Kidney Transplantation
Mice
T-Lymphocytes / immunology
Transplantation Immunology*
Grant Support
ID/Acronym/Agency:
HL52297/HL/NHLBI NIH HHS; HL79067/HL/NHLBI NIH HHS; P01 HL079067/HL/NHLBI NIH HHS; R01 AI048602/AI/NIAID NIH HHS; R37 HL052297/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens; 0/Isoantibodies
Comments/Corrections

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