Document Detail


The paradox of the unfolded protein response in cancer.
MedLine Citation:
PMID:  24222102     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The endoplasmic reticulum (ER) is an elaborate organelle that is essential for cellular function and survival. Conditions that interfere with ER functioning can lead to the accumulation of unfolded proteins, which are detected by transmembrane sensors that then initiate the unfolded protein response (UPR) to restore ER proteostasis. If the adaptive response fails, apoptotic cell death ensues. Many studies have focused on how this failure initiates apoptosis, particularly because ER stress-induced apoptosis is implicated in the pathophysiology of several diseases, including cancer. Whether the UPR inhibits tumour growth or protects tumour cells by facilitating their adaptation to stressful conditions within the tumour microenvironment is unknown, and dissection of the UPR network will likely provide answers to this question. In this review, we aim to elucidate the paradoxical role of the UPR in apoptosis and cancer.
Authors:
Yves-Paul Vandewynckel; Debby Laukens; Anja Geerts; Eliene Bogaerts; Annelies Paridaens; Xavier Verhelst; Sophie Janssens; Femke Heindryckx; Hans VAN Vlierberghe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  33     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  4683-94     Citation Subset:  IM    
Affiliation:
Department of Hepatology and Gastroenterology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium. hans.vanvlierberghe@ugent.be.
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