Document Detail

The paradox of systemic vasodilatation and sympathetic nervous stimulation in space.
MedLine Citation:
PMID:  19651245     Owner:  NLM     Status:  MEDLINE    
Cardiac output is increased by some 18% by weightlessness during the initial week of spaceflight compared to upright standing or sitting on the ground and more so during the initial days of flight than at the end. In addition, mean 24-h diastolic, but not systolic pressure, is significantly decreased by 5mmHg. This is in accordance with observations that very acute weightlessness during parabolic airplane flights and a week of weightlessness in space leads to a decrease in systemic vascular resistance. That the arterial resistance vessels are dilated in space is in contrast to the augmented sympathetic nervous activity and decreased urine production, which have consistently been observed in astronauts in space. These contrasting observations require further investigation.
Peter Norsk; Niels Juel Christensen
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Publication Detail:
Type:  Journal Article     Date:  2009-08-03
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  169 Suppl 1     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  S26-9     Citation Subset:  IM    
Department of Biomedical Sciences, University of Copenhagen, Denmark.
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MeSH Terms
Adaptation, Physiological / physiology
Bed Rest / methods
Blood Pressure / physiology
Cardiac Output / physiology
Peptides / metabolism
Space Flight*
Sympathetic Nervous System / physiology*
Vasodilation / physiology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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