| The paradox of α-adrenergic coronary vasoconstriction revisited. | |
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MedLine Citation:
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PMID: 21458461 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activation of coronary vascular α-adrenoceptors results in vasoconstriction which competes with metabolic vasodilation during sympathetic activation. Epicardial conduit vessel constriction is largely mediated by α(1)-adrenoceptors; the constriction of the resistive microcirculation largely by α(2)-adrenoceptors, but also by α(1)-adrenoceptors. There is no firm evidence that α-adrenergic coronary vasoconstriction exerts a beneficial effect on transmural blood flow distribution. In fact, α-blockade in anesthetized and conscious dogs improves blood flow to all transmural layers, during normoperfusion and hypoperfusion. Also, in patients with coronary artery disease, blockade of α(1)- and α(2)-adrenoceptors improves coronary blood flow, myocardial function and metabolism. |
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Authors:
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Gerd Heusch |
Publication Detail:
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Type: Journal Article; Review Date: 2011-03-30 |
Journal Detail:
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Title: Journal of molecular and cellular cardiology Volume: 51 ISSN: 1095-8584 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-05-27 Completed Date: 2011-09-14 Revised Date: 2012-04-20 |
Medline Journal Info:
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Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: England |
Other Details:
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Languages: eng Pagination: 16-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institut für Pathophysiologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany. gerd.heusch@uk-essen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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metabolism Adrenergic alpha-Antagonists / metabolism Animals Coronary Artery Disease Coronary Circulation / physiology* Coronary Disease / physiopathology Coronary Vessels / metabolism Dogs Heart / physiopathology Humans Ischemia Receptors, Adrenergic, alpha / metabolism* Vasoconstriction / physiology* Vasodilation / physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha |
| Comments/Corrections | |
Republished in:
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J Mol Cell Cardiol. 2012 Apr;52(4):832-9
[PMID:
22420694
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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