Document Detail

The paradox of α-adrenergic coronary vasoconstriction revisited.
MedLine Citation:
PMID:  21458461     Owner:  NLM     Status:  MEDLINE    
Activation of coronary vascular α-adrenoceptors results in vasoconstriction which competes with metabolic vasodilation during sympathetic activation. Epicardial conduit vessel constriction is largely mediated by α(1)-adrenoceptors; the constriction of the resistive microcirculation largely by α(2)-adrenoceptors, but also by α(1)-adrenoceptors. There is no firm evidence that α-adrenergic coronary vasoconstriction exerts a beneficial effect on transmural blood flow distribution. In fact, α-blockade in anesthetized and conscious dogs improves blood flow to all transmural layers, during normoperfusion and hypoperfusion. Also, in patients with coronary artery disease, blockade of α(1)- and α(2)-adrenoceptors improves coronary blood flow, myocardial function and metabolism.
Gerd Heusch
Publication Detail:
Type:  Journal Article; Review     Date:  2011-03-30
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  51     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-05-27     Completed Date:  2011-09-14     Revised Date:  2012-04-20    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  16-23     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Institut für Pathophysiologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany.
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MeSH Terms
Adrenergic alpha-Agonists / metabolism
Adrenergic alpha-Antagonists / metabolism
Coronary Artery Disease
Coronary Circulation / physiology*
Coronary Disease / physiopathology
Coronary Vessels / metabolism
Heart / physiopathology
Receptors, Adrenergic, alpha / metabolism*
Vasoconstriction / physiology*
Vasodilation / physiology
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Receptors, Adrenergic, alpha
Republished in:
J Mol Cell Cardiol. 2012 Apr;52(4):832-9   [PMID:  22420694 ]

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