Document Detail

The par toxin-antitoxin system from Enterococcus faecalis plasmid pAD1 and its chromosomal homologs.
MedLine Citation:
PMID:  23059908     Owner:  NLM     Status:  MEDLINE    
The par post-segregational killing locus present on Enterococcus faecalis plasmid pAD1 was the first Type I toxin-antitoxin system described in Gram-positive bacteria. Translation of the 33 amino acid Fst toxin, encoded on RNA I, is suppressed by a 66 nucleotide regulatory RNA, RNA II. RNA I and RNA II are transcribed convergently and interact at dispersed regions of complementarity, establishing a stable complex that accumulates in plasmid-containing cells. RNA II is slowly removed from the complex, allowing translation of RNA I in plasmid-free segregants. Intramolecular structures are also important for regulating translation of RNA I. The Fst toxin contains a putative transmembrane domain and is believed to exert its function at the bacterial cytoplasmic membrane, although its precise target and mode of action have yet to be determined. Numerous chromosomal homologs of pAD1 par have been identified in Gram-positive bacteria suggesting that this locus may play important roles in cellular function.
Keith E Weaver
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-10-11
Journal Detail:
Title:  RNA biology     Volume:  9     ISSN:  1555-8584     ISO Abbreviation:  RNA Biol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-02-20     Completed Date:  2013-09-11     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  101235328     Medline TA:  RNA Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1498-503     Citation Subset:  IM    
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MeSH Terms
Antitoxins / genetics,  metabolism*
Bacterial Toxins / genetics,  metabolism*
Cell Membrane / genetics,  metabolism
Chromosomes, Bacterial / genetics,  metabolism*
Cytoplasm / metabolism
Enterococcus faecalis / genetics,  metabolism*
Genetic Loci
Nucleic Acid Conformation
Plasmids / genetics,  metabolism
RNA / genetics,  metabolism
RNA Stability
RNA Transport
RNA, Bacterial / immunology,  metabolism*
RNA, Complementary
Regulatory Sequences, Ribonucleic Acid
Grant Support
Reg. No./Substance:
0/Antitoxins; 0/Bacterial Toxins; 0/RNA primers; 0/RNA, Bacterial; 0/RNA, Complementary; 0/Regulatory Sequences, Ribonucleic Acid; 0/fst toxin, Enterococcus faecalis; 63231-63-0/RNA

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