| The pancreatitis-associated protein in hereditary and chronic alcoholic pancreatitis. | |
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MedLine Citation:
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PMID: 10505755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pancreatitis-associated protein (PAP) was investigated in patients with hereditary and chronic alcoholic pancreatitis. Blood levels of pancreatic enzymes and PAP were measured in nine families with hereditary pancreatitis; in three of them, the mutation N21I, and in six, the R117H variant of the cationic trypsinogen were present. In all family members, similar to controls, only normal values of the PAP were found. There was no evidence for polymorphism of the PAP gene in patients with hereditary or alcoholic pancreatitis. Immunohistochemically PAP was detected in the apical parts of the acinar cells but not in ducts, interstitial tissue, islets, or blood vessels. Intensity of PAP labeling was directly related to the deterioration of the acinar units, and its concentration was inversely related to chymotrypsinogen immunoreactivity in the same tissue. Similar immunohistochemical findings were present in chronic alcoholic and hereditary pancreatitis. We conclude that there is a lack of PAP polymorphism in hereditary and alcoholic pancreatitis and that expression of the PAP in both groups of patients is related to the degree of cellular damage of the pancreas. |
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Authors:
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V Keim; A Hoffmeister; N Teich; U Halm; M Scheurlen; A Tannapfel; J M?ssner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pancreas Volume: 19 ISSN: 0885-3177 ISO Abbreviation: Pancreas Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-11-23 Completed Date: 1999-11-23 Revised Date: 2010-02-08 |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 248-54 Citation Subset: IM |
Affiliation:
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Medizinische Klinik und Poliklinik II, Universit?t Leipzig, Germany. keimv@medizin.uni-leipzig.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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genetics,
metabolism* Amino Acid Substitution / genetics Amylases / blood Antigens, Neoplasm* C-Reactive Protein / metabolism Child Chymotrypsinogen / metabolism DNA Mutational Analysis Humans Immunohistochemistry Inflammation / pathology Lectins, C-Type* Lipase / blood Male Mutation Pancreatitis / blood, genetics, metabolism*, pathology Pancreatitis, Alcoholic / blood, metabolism*, pathology Polymerase Chain Reaction Trypsinogen / genetics Tumor Markers, Biological* |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Antigens, Neoplasm; 0/Lectins, C-Type; 0/Tumor Markers, Biological; 0/pancreatitis-associated protein; 9002-08-8/Trypsinogen; 9007-41-4/C-Reactive Protein; 9035-75-0/Chymotrypsinogen; EC 3.1.1.3/Lipase; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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