| The pancreatic islets in spontaneously hypertensive rats: islet blood flow and insulin production. | |
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MedLine Citation:
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PMID: 11182754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to investigate if hypertension affects pancreatic islet blood flow and endocrine function. For this purpose, spontaneously hypertensive rats (SHR) were compared with normotensive control Wistar-Kyoto rats (WKY). Both islet size and islet cell replication in 4-month-old SHR was increased compared with WKY. The (pro)insulin biosynthesis was reduced in islets isolated from SHR, whereas the insulin content was unchanged. A hyperinsulinemic response to glucose in vivo was observed in 4- and 12-month-old SHR. Pancreatic blood flow, measured using a microsphere technique, was lower in SHR than in WKY in rats aged 5 weeks, 4 months or 1 year. Islet blood flow was lower in 4-month-old and 1-year-old SHR. In 4-month-old animals, islet blood flow was unaffected by administration of enalaprilate and prazosin in both strains, but was markedly decreased by the administration of N(G)-methyl-L-arginine. It was concluded that the islets of SHR have a decreased insulin production in vitro and a decreased islet blood perfusion. The reasons for this are likely to be multifactorial. Because SHR maintained an essentially normal glucose tolerance, an adaptation of the beta-cells to the metabolic and hemodynamic changes imposed by hypertension occurred. |
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Authors:
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M Iwase; S Sandler; P O Carlsson; C Hellerström; L Jansson |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 144 ISSN: 0804-4643 ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-03-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 169-78 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, SE-751 23 Uppsala, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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pharmacology Aging / physiology Angiotensin-Converting Enzyme Inhibitors / pharmacology Animals Antihypertensive Agents / pharmacology Blood Glucose / analysis DNA / metabolism Enalaprilat / pharmacology Enzyme Inhibitors / pharmacology Hypertension / pathology, physiopathology* Insulin / biosynthesis*, blood Islets of Langerhans / blood supply*, metabolism*, pathology Prazosin / pharmacology Rats Rats, Inbred SHR / physiology* Rats, Inbred WKY omega-N-Methylarginine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Blood Glucose; 0/Enzyme Inhibitors; 11061-68-0/Insulin; 17035-90-4/omega-N-Methylarginine; 19216-56-9/Prazosin; 84680-54-6/Enalaprilat; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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