| Is pancreatic core biopsy sufficient to diagnose autoimmune chronic pancreatitis? | |
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MedLine Citation:
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PMID: 18192887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This study aimed to evaluate the adequacy of pancreatic core biopsy in histological diagnosis of autoimmune chronic pancreatitis (AIP). METHODS: Histopathologic study as well as immunohistochemical staining using anti-IgG4 antibody was done with pancreatic tissue specimens of 26 AIP patients (19 transabdominal ultrasound (US)-guided core biopsies, 3 intraoperative wedge biopsies, and 4 surgical resections). Eight patients with alcoholic chronic pancreatitis and 10 patients with pancreatic cancer served as controls. RESULTS: Lymphoplasmacytic sclerosing pancreatitis (LPSP) histology was observed in 26% (5/19) of US-guided core biopsy specimens, 33% (1/3) of open biopsy specimens, and all 4 resection specimens in AIP patients. None of the patients in the control group showed the full spectrum of changes of LPSP. Abundant IgG4-positive cells (>10 cells/high-power field) in the pancreas were observed in 21% (4/19) of AIP patients with US-guided core biopsy specimen. Abundant IgG4-positive cells in the pancreas were also observed in 2 of 8 patients with chronic alcoholic pancreatitis and 1 of 10 patients with pancreatic cancer. CONCLUSIONS: Transabdominal US-guided pancreatic core biopsy may not provide enough tissue to evaluate characteristic histopathologic features of AIP that include LPSP or abundant IgG4-positive cell infiltration. The LPSP histology may be specific to AIP, but abundant IgG4-positive cells in the pancreas may not. |
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Authors:
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Sung-Jo Bang; Myung-Hwan Kim; Do Ha Kim; Tae Yoon Lee; Seunghyun Kwon; Hyoung-Chul Oh; Ji Young Kim; Chang Yun Hwang; Sang Soo Lee; Dong Wan Seo; Sung Koo Lee; Dong Eun Song; Se Jin Jang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pancreas Volume: 36 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-14 Completed Date: 2008-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: 84-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Autoimmune Diseases / pathology* Biopsy / methods* Female Humans Immunoglobulin G Immunohistochemistry Male Middle Aged Pancreatic Neoplasms / pathology Pancreatitis, Alcoholic / pathology Pancreatitis, Chronic / immunology*, pathology*, surgery Sensitivity and Specificity Ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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