Document Detail


Is pancreatic core biopsy sufficient to diagnose autoimmune chronic pancreatitis?
MedLine Citation:
PMID:  18192887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: This study aimed to evaluate the adequacy of pancreatic core biopsy in histological diagnosis of autoimmune chronic pancreatitis (AIP). METHODS: Histopathologic study as well as immunohistochemical staining using anti-IgG4 antibody was done with pancreatic tissue specimens of 26 AIP patients (19 transabdominal ultrasound (US)-guided core biopsies, 3 intraoperative wedge biopsies, and 4 surgical resections). Eight patients with alcoholic chronic pancreatitis and 10 patients with pancreatic cancer served as controls. RESULTS: Lymphoplasmacytic sclerosing pancreatitis (LPSP) histology was observed in 26% (5/19) of US-guided core biopsy specimens, 33% (1/3) of open biopsy specimens, and all 4 resection specimens in AIP patients. None of the patients in the control group showed the full spectrum of changes of LPSP. Abundant IgG4-positive cells (>10 cells/high-power field) in the pancreas were observed in 21% (4/19) of AIP patients with US-guided core biopsy specimen. Abundant IgG4-positive cells in the pancreas were also observed in 2 of 8 patients with chronic alcoholic pancreatitis and 1 of 10 patients with pancreatic cancer. CONCLUSIONS: Transabdominal US-guided pancreatic core biopsy may not provide enough tissue to evaluate characteristic histopathologic features of AIP that include LPSP or abundant IgG4-positive cell infiltration. The LPSP histology may be specific to AIP, but abundant IgG4-positive cells in the pancreas may not.
Authors:
Sung-Jo Bang; Myung-Hwan Kim; Do Ha Kim; Tae Yoon Lee; Seunghyun Kwon; Hyoung-Chul Oh; Ji Young Kim; Chang Yun Hwang; Sang Soo Lee; Dong Wan Seo; Sung Koo Lee; Dong Eun Song; Se Jin Jang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  36     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.
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MeSH Terms
Descriptor/Qualifier:
Aged
Autoimmune Diseases / pathology*
Biopsy / methods*
Female
Humans
Immunoglobulin G
Immunohistochemistry
Male
Middle Aged
Pancreatic Neoplasms / pathology
Pancreatitis, Alcoholic / pathology
Pancreatitis, Chronic / immunology*,  pathology*,  surgery
Sensitivity and Specificity
Ultrasonography
Chemical
Reg. No./Substance:
0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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