Document Detail

Is pancreatic core biopsy sufficient to diagnose autoimmune chronic pancreatitis?
MedLine Citation:
PMID:  18192887     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study aimed to evaluate the adequacy of pancreatic core biopsy in histological diagnosis of autoimmune chronic pancreatitis (AIP). METHODS: Histopathologic study as well as immunohistochemical staining using anti-IgG4 antibody was done with pancreatic tissue specimens of 26 AIP patients (19 transabdominal ultrasound (US)-guided core biopsies, 3 intraoperative wedge biopsies, and 4 surgical resections). Eight patients with alcoholic chronic pancreatitis and 10 patients with pancreatic cancer served as controls. RESULTS: Lymphoplasmacytic sclerosing pancreatitis (LPSP) histology was observed in 26% (5/19) of US-guided core biopsy specimens, 33% (1/3) of open biopsy specimens, and all 4 resection specimens in AIP patients. None of the patients in the control group showed the full spectrum of changes of LPSP. Abundant IgG4-positive cells (>10 cells/high-power field) in the pancreas were observed in 21% (4/19) of AIP patients with US-guided core biopsy specimen. Abundant IgG4-positive cells in the pancreas were also observed in 2 of 8 patients with chronic alcoholic pancreatitis and 1 of 10 patients with pancreatic cancer. CONCLUSIONS: Transabdominal US-guided pancreatic core biopsy may not provide enough tissue to evaluate characteristic histopathologic features of AIP that include LPSP or abundant IgG4-positive cell infiltration. The LPSP histology may be specific to AIP, but abundant IgG4-positive cells in the pancreas may not.
Sung-Jo Bang; Myung-Hwan Kim; Do Ha Kim; Tae Yoon Lee; Seunghyun Kwon; Hyoung-Chul Oh; Ji Young Kim; Chang Yun Hwang; Sang Soo Lee; Dong Wan Seo; Sung Koo Lee; Dong Eun Song; Se Jin Jang
Related Documents :
21178377 - Impact of hypovitaminosis d and alfacalcidol therapy on survival of hemodialysis patien...
2210197 - Ct detection of asymptomatic pancreatitis following ercp.
19890187 - Zinc status in chronic pancreatitis and its relationship with exocrine and endocrine in...
9930947 - Pancreatic islet autotransplantation combined with total pancreatectomy for the treatme...
15683487 - Edrophonium-induced right ventricular outflow tract tachycardia.
18807 - Dilemmas in the early diagnosis and treatment of multiple endocrine adenomatosis, type ii.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  36     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-9     Citation Subset:  IM    
Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Autoimmune Diseases / pathology*
Biopsy / methods*
Immunoglobulin G
Middle Aged
Pancreatic Neoplasms / pathology
Pancreatitis, Alcoholic / pathology
Pancreatitis, Chronic / immunology*,  pathology*,  surgery
Sensitivity and Specificity
Reg. No./Substance:
0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neop...
Next Document:  Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1 polymorphi...