| The pancreas in acute graft versus host disease in man. | |
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MedLine Citation:
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PMID: 2707748 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-six bone marrow transplant recipients, 14 of whom had evidence of acute graft versus host disease at autopsy, were studied. The pancreas in four of these patients exhibited changes thought to be due to acute graft versus host disease. Pathognomonic findings were in exocrine ducts which showed marked epithelial cellular atypia associated with a mild lymphocytic infiltrate. This was accompanied by ulceration and intraluminal haemorrhage in severe cases. In three of these four cases ductal epithelium showed marked hyperexpression of class I and class II major histocompatibility complex molecules. By contrast islets were not inflamed, showed no evidence of endocrine cell damage and no abnormalities of major histocompatibility complex expression were seen. |
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Authors:
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A K Foulis; M A Farquharson; G E Sale |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Histopathology Volume: 14 ISSN: 0309-0167 ISO Abbreviation: Histopathology Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-06-01 Completed Date: 1989-06-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 121-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, Royal Infirmary, Glasgow, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool Female Graft vs Host Disease / immunology, pathology* HLA Antigens / metabolism Humans Male Pancreatic Diseases / etiology, immunology, pathology* |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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