| A palm-sized surface plasmon resonance sensor with microchip flow cell. | |
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MedLine Citation:
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PMID: 18970786 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A small-sized surface plasmon resonance (SPR) sensor with a microchip flow cell has been developed for the purpose of enhancing the sensitivity of the SPR detector for low molecular weight compounds. This portable differential SPR detector consisted of an LED, two cylindrical lenses, a round prism, a divided mirror, a CCD, electronics, and a polydimethylsiloxane/gold microchip with two flow paths (10mm long, 1mm wide, 20-100mum deep). 3-Mercaptopropyltrimethoxysilane was used for sealing the microchip. The performance of the on-site orientated SPR detector was estimated using sucrose and IgA. A drastic change in the SPR intensity appeared. The depth of the flow cell was in inverse proportion to the SPR intensity. Compared to a conventional flow cell having the size of 10mm (L)x1mm (W)x1mm (D), its sensitivity to 10% sucrose and 0.9nM IgA increased about 11 and 39 times, respectively. This phenomenon seemed to be due to the increase in the substance on the SPR sensor based on its size effect. These results showed that the application of the microchip sensor for SPR measurement has the possibility for improvement of the SPR intensity for low molecular substances. |
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Authors:
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Hizuru Nakajima; Yuuki Harada; Yasukazu Asano; Tatsuro Nakagama; Katsumi Uchiyama; Toshihiko Imato; Nobuaki Soh; Akihide Hemmi |
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Publication Detail:
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Type: Journal Article Date: 2006-07-03 |
Journal Detail:
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Title: Talanta Volume: 70 ISSN: 1873-3573 ISO Abbreviation: Talanta Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2008-10-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984816R Medline TA: Talanta Country: England |
Other Details:
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Languages: eng Pagination: 419-25 Citation Subset: - |
Affiliation:
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Faculty of Urban Environmental Sciences, Tokyo Metropolitan University, 1-1 Minamiohsawa, Hachioji, Tokyo 192-0364, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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