| A pairwise maximum entropy model accurately describes resting-state human brain networks. | |
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MedLine Citation:
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PMID: 23340410 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The resting-state human brain networks underlie fundamental cognitive functions and consist of complex interactions among brain regions. However, the level of complexity of the resting-state networks has not been quantified, which has prevented comprehensive descriptions of the brain activity as an integrative system. Here, we address this issue by demonstrating that a pairwise maximum entropy model, which takes into account region-specific activity rates and pairwise interactions, can be robustly and accurately fitted to resting-state human brain activities obtained by functional magnetic resonance imaging. Furthermore, to validate the approximation of the resting-state networks by the pairwise maximum entropy model, we show that the functional interactions estimated by the pairwise maximum entropy model reflect anatomical connexions more accurately than the conventional functional connectivity method. These findings indicate that a relatively simple statistical model not only captures the structure of the resting-state networks but also provides a possible method to derive physiological information about various large-scale brain networks. |
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Authors:
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Takamitsu Watanabe; Satoshi Hirose; Hiroyuki Wada; Yoshio Imai; Toru Machida; Ichiro Shirouzu; Seiki Konishi; Yasushi Miyashita; Naoki Masuda |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nature communications Volume: 4 ISSN: 2041-1723 ISO Abbreviation: Nat Commun Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101528555 Medline TA: Nat Commun Country: England |
Other Details:
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Languages: eng Pagination: 1370 Citation Subset: IM |
Affiliation:
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Department of Physiology, The University of Tokyo School of Medicine, Tokyo 113-0033, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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