Document Detail

A pair-feeding study reveals that a Y5 antagonist causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
MedLine Citation:
PMID:  17105869     Owner:  NLM     Status:  MEDLINE    
Neuropeptide Y (NPY) is thought to have a significant role in the physiological control of energy homeostasis. We recently reported that an NPY Y5 antagonist inhibits body weight gain in diet-induced obese (DIO) mice, with a moderate reduction in food intake. To clarify the mechanism of the antiobesity effects of the Y5 antagonist, we conducted a pair-feeding study in DIO mice. The Y5 antagonist at 100 mg/kg produced a moderate feeding suppression leading to an 18% decrease in body weight, without altering body temperature. In contrast, the pair-fed group showed only a transient weight reduction and a reduced body temperature, thus indicating that the Y5 antagonist stimulates thermogenesis. The Y5 antagonist-treated mice showed an up-regulation of uncoupling protein mRNA in brown adipose tissue (BAT) and white adipose tissue (WAT), suggesting that both BAT and WAT contribute to energy expenditure. Thus, the Y5 antagonist induces its antiobesity effects by acting on both energy intake and expenditure.
Satoshi Mashiko; Akane Ishihara; Hisashi Iwaasa; Hideki Sano; Junko Ito; Akira Gomori; Zenjun Oda; Ryuichi Moriya; Hiroko Matsushita; Makoto Jitsuoka; Osamu Okamoto; Douglas J MacNeil; Lex H T Van der Ploeg; Takehiro Fukami; Akio Kanatani
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Publication Detail:
Type:  Journal Article     Date:  2006-11-14
Journal Detail:
Title:  Molecular pharmacology     Volume:  71     ISSN:  0026-895X     ISO Abbreviation:  Mol. Pharmacol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-22     Completed Date:  2007-03-01     Revised Date:  2007-05-10    
Medline Journal Info:
Nlm Unique ID:  0035623     Medline TA:  Mol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  602-8     Citation Subset:  IM    
Tsukuba Research Institute, Banyu Pharmaceutical Co. Ltd., Okubo 3, Tsukuba 300-2611, Japan.
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MeSH Terms
Adipose Tissue
Body Temperature
Eating / drug effects*
Energy Intake / drug effects
Energy Metabolism / drug effects*
Ion Channels / genetics
Mice, Inbred C57BL
Mitochondrial Proteins / genetics
Obesity / drug therapy
Receptors, Neuropeptide Y / antagonists & inhibitors*
Up-Regulation / drug effects
Weight Loss / drug effects*
Reg. No./Substance:
0/Ion Channels; 0/Mitochondrial Proteins; 0/Receptors, Neuropeptide Y; 0/mitochondrial uncoupling protein; 0/neuropeptide Y5 receptor
Erratum In:
Mol Pharmacol. 2007 May;71(5):1444

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