Document Detail

The pacemaker activity of interstitial cells of Cajal and gastric electrical activity.
MedLine Citation:
PMID:  12790758     Owner:  NLM     Status:  MEDLINE    
Interstitial cells of Cajal (ICC) are the pacemaker cells in the gut. They have special properties that make them unique in their ability to generate and propagate slow waves in gastrointestinal muscles. The electrical slow wave activity determines the characteristic frequency of phasic contractions of the stomach, intestine and colon. Slow waves also determine the direction and velocity of propagation of peristaltic activity, in concert with the enteric nervous system. Characterization of receptors and ion channels in the ICC membrane is under way, and manipulation of slow wave activity markedly alters the movement of contents through the gut. Gastric myoelectrical slow wave activity produced by pacemaker cells (ICC) can be reflected by electrogastrography (EGG). Electrogastrography is a perspective non-invasive method that can detect gastric dysrhythmias associated with symptoms of nausea or delayed gastric emptying.
P Camborová; P Hubka; I Sulková; I Hulín
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  52     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2003  
Date Detail:
Created Date:  2003-06-06     Completed Date:  2004-04-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  275-84     Citation Subset:  IM    
Department of Pathophysiology, Faculty of Medicine, Commenius University, Bratislava, Slovak Republic.
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MeSH Terms
Biological Clocks / physiology*
Enteric Nervous System / physiology
Gastrointestinal Tract / cytology,  physiology
Ion Channels / physiology
Mesoderm / cytology,  physiology
Myocytes, Smooth Muscle / physiology
Peristalsis / physiology*
Proto-Oncogene Proteins c-kit / physiology
Reg. No./Substance:
0/Ion Channels; EC Proteins c-kit

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