| pH-stimuli-responsive near-infrared optical imaging nanoprobe based on poly(γ-glutamic acid)/poly(β-amino ester) nanoparticles. | |
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MedLine Citation:
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PMID: 22033077 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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pH-stimuli-responsive near-infrared optical imaging nanoprobes are designed and synthesized in this study in a facile one-step synthesis process based on the use of the biocompatible and biodegradable polymer poly(γ-glutamic acid) (γ-PGA)/poly(β-amino ester) (PBAE). PBAE has good transfection efficiency and promotes degradation properties under acidic conditions. This pH-responsive degradability can be used for the effective release of encapsulating materials after cellular uptake. As an optical imaging probe, indocyanine green (ICG) is an FDA-approved near-infrared fluorescent dye with a quenching property at a high concentration. In this regard, we focus here on the rapid degradation of PBAE in an acidic environment, in which the nanoparticles are disassembled. This allows the ICG dyes to show enhanced fluorescence signals after being releasing from the particles. We demonstrated this principle in cellular uptake experiments. We expect that the developed pH-stimuli-responsive smart nanoprobes can be applied in intracellular delivery signaling applications. |
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Authors:
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Hye Sun Park; Jung Eun Lee; Mi Young Cho; Young-Woock Noh; Moon Hee Sung; Haryoung Poo; Kwan Soo Hong; Yong Taik Lim |
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Publication Detail:
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Type: Journal Article Date: 2011-10-27 |
Journal Detail:
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Title: Nanotechnology Volume: 22 ISSN: 1361-6528 ISO Abbreviation: Nanotechnology Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101241272 Medline TA: Nanotechnology Country: England |
Other Details:
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Languages: eng Pagination: 465603 Citation Subset: IM |
Affiliation:
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Graduate School and Department of Analytical Science and Technology, Chungnam National University, Yuseong-gu, Daejeon 305-764, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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