| pH-sensitive mutagenic activity in ozone-treated 1,2-dimethylhydrazine in the Salmonella/microsome assay. | |
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MedLine Citation:
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PMID: 7048084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment with ozone inactivates the mutagenicity of many carcinogens in aqueous solution. The colon carcinogen, 1,2-dimethylhydrazine (DMH) has been reported an exception; ozone treatment converts dimethylhydrazine from a non-mutagen into a mutagen. In the Salmonella/microsome assay, the mutagenicity of ozone-treated dimethylhydrazine was dependent on pH. The ozonation product was a strong mutagen in acidic solution but was not mutagenic in basic solution. The mutagenicity of the acidic ozonation product was inactivated by raising the pH of the solution. Unlike untreated dimethylhydrazine, its ozonation product in basic solution was not converted to a mutagen in this ozone-low pH system. |
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Authors:
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T M Chambers; G R Burleson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Mutation research Volume: 94 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1982 May |
Date Detail:
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Created Date: 1982-09-10 Completed Date: 1982-09-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 23-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1,2-Dimethylhydrazine Animals Carcinogens / pharmacology* Dimethylhydrazines / pharmacology* Hydrogen-Ion Concentration Methylhydrazines / pharmacology* Mutagenicity Tests Mutagens / pharmacology* Oxygen / pharmacology Ozone / pharmacology* Rats Salmonella typhimurium / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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CA 15957-08/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Dimethylhydrazines; 0/Methylhydrazines; 0/Mutagens; 10028-15-6/Ozone; 540-73-8/1,2-Dimethylhydrazine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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