Document Detail

pH-sensitive mutagenic activity in ozone-treated 1,2-dimethylhydrazine in the Salmonella/microsome assay.
MedLine Citation:
PMID:  7048084     Owner:  NLM     Status:  MEDLINE    
Treatment with ozone inactivates the mutagenicity of many carcinogens in aqueous solution. The colon carcinogen, 1,2-dimethylhydrazine (DMH) has been reported an exception; ozone treatment converts dimethylhydrazine from a non-mutagen into a mutagen. In the Salmonella/microsome assay, the mutagenicity of ozone-treated dimethylhydrazine was dependent on pH. The ozonation product was a strong mutagen in acidic solution but was not mutagenic in basic solution. The mutagenicity of the acidic ozonation product was inactivated by raising the pH of the solution. Unlike untreated dimethylhydrazine, its ozonation product in basic solution was not converted to a mutagen in this ozone-low pH system.
T M Chambers; G R Burleson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mutation research     Volume:  94     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  IM    
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MeSH Terms
Carcinogens / pharmacology*
Dimethylhydrazines / pharmacology*
Hydrogen-Ion Concentration
Methylhydrazines / pharmacology*
Mutagenicity Tests
Mutagens / pharmacology*
Oxygen / pharmacology
Ozone / pharmacology*
Salmonella typhimurium / drug effects*
Grant Support
CA 15957-08/CA/NCI NIH HHS
Reg. No./Substance:
0/Carcinogens; 0/Dimethylhydrazines; 0/Methylhydrazines; 0/Mutagens; 10028-15-6/Ozone; 540-73-8/1,2-Dimethylhydrazine; 7782-44-7/Oxygen

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