Document Detail

pH response of human dental plaque to chewing gum supplemented with low molecular chitosan.
MedLine Citation:
PMID:  7987965     Owner:  NLM     Status:  MEDLINE    
The effects of low molecular chitosan (LMCS) on pH responses of human dental plaque following exposure to fermentable carbohydrates were investigated by an ion-sensitive field-effect transistor electrode system. After the plaque pH values were minimized by direct application of 5% glucose solution or consumption of sugared caramel, the subjects started chewing the test gums containing 0 (control), 1 or 3% (w/w) LMCS for three minutes. The pH response was monitored until it recovered to over pH5.5. In the case of the glucose solution, chewing 3% LMCS gum caused significantly more rapid pH recovery toward the resting level than did the control gum. Initial pH rising rate during gum chewing was faster with either of the two LMCS gums than with the control gum. In the case of caramel, additional effects of LMCS were observed numerically as LMCS content increased. The findings indicated that LMCS had a potential to promote recovery of plaque pH after acidogenic challenge and to maintain the plaque pH around neutrality.
K Shibasaki; H Sano; T Matsukubo; Y Takaesu
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Bulletin of Tokyo Dental College     Volume:  35     ISSN:  0040-8891     ISO Abbreviation:  Bull. Tokyo Dent. Coll.     Publication Date:  1994 May 
Date Detail:
Created Date:  1995-01-06     Completed Date:  1995-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505414     Medline TA:  Bull Tokyo Dent Coll     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  D    
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MeSH Terms
Chewing Gum*
Chitin / analogs & derivatives*,  pharmacology
Dental Plaque / chemistry*
Glucose / metabolism
Hydrogen-Ion Concentration / drug effects
Reg. No./Substance:
0/Buffers; 0/Chewing Gum; 1398-61-4/Chitin; 50-99-7/Glucose; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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