| pH-lactate dissociation during anoxic insult: taurine effect. | |
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MedLine Citation:
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PMID: 1912466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Taurine, a sulfur amino acid abundant in brain of the fetus and early day neonate, has been postulated to play a major role in mediating the immature brain's unusually high buffering ability for lactic acidosis reported previously. In this study, we directly investigated this 'taurine effect' using a 10-day-old rat pup model and multinuclear (31P and 1H) nuclear magnetic resonance (NMR) in-vivo spectroscopy. Brain of taurine-supplemented pups exhibited significantly higher acid buffering ability against lactic acidosis than age-matched control pups. The study supports the hypothesis that high levels of free cytosolic taurine increase the brain's ability to buffer against lactic acidosis. |
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Authors:
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T Nakada; K Hida; I L Kwee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroreport Volume: 2 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-11-13 Completed Date: 1991-11-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 325-8 Citation Subset: IM |
Affiliation:
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Neurochemistry Research Laboratory, Department of Veterans Affairs Medical Center, Martinez, CA 94553. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Anoxia / blood* Brain Chemistry / drug effects* Hydrogen-Ion Concentration Lactates / blood* Magnetic Resonance Spectroscopy Phosphocreatine / metabolism Phosphorus Isotopes Rats Rats, Inbred Strains Respiration / drug effects Taurine / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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GM37197/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Phosphorus Isotopes; 107-35-7/Taurine; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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