Document Detail

pH-lactate dissociation during anoxic insult: taurine effect.
MedLine Citation:
PMID:  1912466     Owner:  NLM     Status:  MEDLINE    
Taurine, a sulfur amino acid abundant in brain of the fetus and early day neonate, has been postulated to play a major role in mediating the immature brain's unusually high buffering ability for lactic acidosis reported previously. In this study, we directly investigated this 'taurine effect' using a 10-day-old rat pup model and multinuclear (31P and 1H) nuclear magnetic resonance (NMR) in-vivo spectroscopy. Brain of taurine-supplemented pups exhibited significantly higher acid buffering ability against lactic acidosis than age-matched control pups. The study supports the hypothesis that high levels of free cytosolic taurine increase the brain's ability to buffer against lactic acidosis.
T Nakada; K Hida; I L Kwee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroreport     Volume:  2     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-11-13     Completed Date:  1991-11-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  325-8     Citation Subset:  IM    
Neurochemistry Research Laboratory, Department of Veterans Affairs Medical Center, Martinez, CA 94553.
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MeSH Terms
Adenosine Triphosphate / metabolism
Anoxia / blood*
Brain Chemistry / drug effects*
Hydrogen-Ion Concentration
Lactates / blood*
Magnetic Resonance Spectroscopy
Phosphocreatine / metabolism
Phosphorus Isotopes
Rats, Inbred Strains
Respiration / drug effects
Taurine / pharmacology*
Grant Support
Reg. No./Substance:
0/Lactates; 0/Phosphorus Isotopes; 107-35-7/Taurine; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

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