| pH-controlled, polymer-mediated assembly of polymer micelle nanoparticles. | |
| | |
MedLine Citation:
|
PMID: 17209598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We describe pH-controlled, polymer-mediated assembly of polymer micelles in aqueous media based on reversible complexation between the micelles of pyrene-labeled poly(epsilon-caprolactone)-b-poly(carboxylic acid) copolymers and proton-accepting water-soluble polymers such as poly(ethylene glycol) (PEG), poly(2-ethyl-2-oxazoline) (PEtOz), and poly(1-vinylpyrrolidone) (PVP). The key factor determining assembly phenomena was identified as the modulation of hydrogen-bonding interaction between ionizable anionic micellar shells and the proton-accepting polymers by the pH control. As pH decreased from 7.4 to 2.0, the mixture of the polymer micelles and polymers underwent assembly and formed solid hybrids at specific pH values. The micelles assembled in the hybrid could be reversibly dispersed as micelles above specific pH ranges. The assembly/disassembly behavior as well as phase transitions of the micelle/proton-accepting polymer could be precisely controlled by adjusting pH. This assembling behavior depended on the rationally designed parameters such as the chemical structure and length of micellar shell-forming poly(carboxylic acid)s and the class of proton-accepting polymers. |
| | |
Authors:
|
Sang Cheon Lee; Hong Jae Lee |
Related Documents
:
|
16853748 - Real structure of formamide entrapped by aot nonaqueous reverse micelles: ft-ir and 1h ... 12604038 - Isothermic titration calorimetry to study cmcs of neutral surfactants and of the liposo... 19788308 - Functional disulfide-stabilized polymer-protein particles. 19681628 - Gemini surfactant electrospun membranes. 15137778 - Solvent-induced self-assembly of mixed poly(methyl methacrylate)/polystyrene brushes on... 9813838 - Cholinesterase activity in white-winged doves exposed to methyl parathion. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Langmuir : the ACS journal of surfaces and colloids Volume: 23 ISSN: 0743-7463 ISO Abbreviation: Langmuir Publication Date: 2007 Jan |
Date Detail:
|
Created Date: 2007-01-09 Completed Date: 2007-07-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9882736 Medline TA: Langmuir Country: United States |
Other Details:
|
Languages: eng Pagination: 488-95 Citation Subset: IM |
Affiliation:
|
Nanomaterials Application Division, Korea Institute of Ceramic Engineering and Technology, Seoul 153-801, Korea. sclee@kicet.re.kr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chemistry, Physical
/
methods Drug Carriers / chemistry Hydrogen-Ion Concentration Micelles* Microscopy, Electron, Transmission Models, Chemical Nanoparticles / chemistry* Nanotechnology / methods Particle Size Polyethylene Glycols / chemistry Polymers / chemistry* Solubility Spectrophotometry Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Drug Carriers; 0/Micelles; 0/Polyethylene Glycols; 0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Self-organization of a wedge-shaped surfactant in monolayers and multilayers.
Next Document: Liquid crystalline phases and their dispersions in aqueous mixtures of glycerol monooleate and glyce...