Document Detail

pH-adjusted formula and gastroesophageal reflux.
MedLine Citation:
PMID:  2061777     Owner:  NLM     Status:  MEDLINE    
To facilitate the detection of postcibal gastroesophageal reflux (GER), we have constructed an infant formula from modular carbohydrate, fat, and protein components with a pH of 4 and a nutrient composition identical to standard infant formula. In comparison to standard infant formula and sugar solutions, this pH-adjusted formula demonstrates a significantly greater amount of gastroesophageal reflex during the first postcibal hour. We speculate that the greater caloric density and slower gastric emptying of regular infant formula promotes greater gastroesophageal reflux than is observed with regular dextrose feedings. This effect is obscured unless the pH of the formula is adjusted. Use of this weakly acid formula in conjunction with postcibal esophageal pH probe recording facilitates the detection and, during simultaneous apnea monitoring, potential association of symptoms with postcibal gastroesophageal reflux.
J L Sutphen; V L Dillard
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  12     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-08-02     Completed Date:  1991-08-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  48-51     Citation Subset:  IM    
University of Virginia, Children's Medical Center, Department of Pediatrics, Charlottesville 22908.
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MeSH Terms
Gastroesophageal Reflux / diagnosis*
Hydrogen-Ion Concentration*
Infant Food*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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