| pH-Dependent biodegradable silica nanotubes derived from Gd(OH)3 nanorods and their potential for oral drug delivery and MR imaging. | |
| | |
MedLine Citation:
|
PMID: 20542331 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We report a pH dependence of degradable silica nanotubes, which dissolved to the biodegradation product monosilicic acid, Si(OH)(4). The silica nanotubes, potentially acting as oral-based administration carriers, were resistant to dissolution in the extreme acidic condition of pH 1, but degraded quickly at pH 8, and the degradation rate can be tuned by tailoring the thickness of silica nanotubes with thicker nanotubes dissolving more slowly. Because Gd(OH)(3) nanorods were used as templates, the silica nanotubes could be further developed as MR imaging contrast agents as well as drugs carriers. The released Gd(3+) ions resulting from the etching of Gd(OH)(3) nanorods were chelated by the pre-modified DOTA, yielding Gd-DOTA complexes grafted onto silica nanotubes. The Gd-DOTA grafted silica nanotubes loaded with doxorubicin revealed enhanced T(1) imaging contrast and anticancer activity. |
| | |
Authors:
|
Kuo-Wei Hu; Kang-Che Hsu; Chen-Sheng Yeh |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-12 |
Journal Detail:
|
Title: Biomaterials Volume: 31 ISSN: 1878-5905 ISO Abbreviation: Biomaterials Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-07-12 Completed Date: 2010-10-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
|
Languages: eng Pagination: 6843-8 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Biocompatible Materials / pharmacology* Camptothecin / pharmacology Drug Delivery Systems / methods* Gadolinium / chemistry* Hela Cells Heterocyclic Compounds Humans Hydrogen-Ion Concentration / drug effects Hydroxides / chemistry* Magnetic Resonance Imaging* Magnetic Resonance Spectroscopy Microscopy, Confocal Nanotubes / chemistry*, ultrastructure Organometallic Compounds Silicon Dioxide / chemistry* Temperature Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Biocompatible Materials; 0/Heterocyclic Compounds; 0/Hydroxides; 0/Organometallic Compounds; 7440-54-2/Gadolinium; 7631-86-9/Silicon Dioxide; 7689-03-4/Camptothecin; 92923-44-9/gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The performance of a hydrogel nucleus pulposus prosthesis in an ex vivo canine model.
Next Document: The effect of immobilized RGD peptide in macroporous alginate scaffolds on TGFbeta1-induced chondrog...