Document Detail


p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress.
MedLine Citation:
PMID:  22902070     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in cardiomyocytes may protect against proteotoxic stress in the heart. p62 may serve as a proteotoxic stress sensor, promote segregation and degradation of misfolded proteins by autophagy, and mediate the cross talk between the ubiquitin-proteasome system and autophagy.
Authors:
Huabo Su; Xuejun Wang
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  21     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2013-01-11     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  224-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Protein Quality Control and Degradation Research Center and Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, SD 57069, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / metabolism*
Animals
Autophagy*
Heart Diseases / enzymology*,  pathology
Humans
Myocardium / enzymology*,  pathology
Proteasome Endopeptidase Complex / metabolism*
Protein Folding
Proteostasis Deficiencies / enzymology*,  pathology
Signal Transduction*
Stress, Physiological*
Ubiquitin / metabolism*
Up-Regulation
Grant Support
ID/Acronym/Agency:
R01 HL068936/HL/NHLBI NIH HHS; R01 HL072166/HL/NHLBI NIH HHS; R01 HL085629/HL/NHLBI NIH HHS; R01HL068936/HL/NHLBI NIH HHS; R01HL072166/HL/NHLBI NIH HHS; R01HL085629/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/SQSTM1 protein, human; 0/Ubiquitin; EC 3.4.25.1/Proteasome Endopeptidase Complex
Comments/Corrections

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