| p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress. | |
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MedLine Citation:
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PMID: 22902070 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As exemplified by desmin-related cardiomyopathy and myocardial ischemia/reperfusion injury, proteasome functional insufficiency plays an essential pathogenic role in the progression of cardiac diseases with elevated proteotoxic stress. Upregulation of p62/SQSTM1 and increased selective autophagy in cardiomyocytes may protect against proteotoxic stress in the heart. p62 may serve as a proteotoxic stress sensor, promote segregation and degradation of misfolded proteins by autophagy, and mediate the cross talk between the ubiquitin-proteasome system and autophagy. |
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Authors:
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Huabo Su; Xuejun Wang |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 21 ISSN: 1873-2615 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-08-20 Completed Date: 2013-01-11 Revised Date: 2013-04-02 |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 224-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Protein Quality Control and Degradation Research Center and Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, SD 57069, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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metabolism* Animals Autophagy* Heart Diseases / enzymology*, pathology Humans Myocardium / enzymology*, pathology Proteasome Endopeptidase Complex / metabolism* Protein Folding Proteostasis Deficiencies / enzymology*, pathology Signal Transduction* Stress, Physiological* Ubiquitin / metabolism* Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL068936/HL/NHLBI NIH HHS; R01 HL072166/HL/NHLBI NIH HHS; R01 HL085629/HL/NHLBI NIH HHS; R01HL068936/HL/NHLBI NIH HHS; R01HL072166/HL/NHLBI NIH HHS; R01HL085629/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/SQSTM1 protein, human; 0/Ubiquitin; EC 3.4.25.1/Proteasome Endopeptidase Complex |
| Comments/Corrections | |
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