| p59fyn is associated with the development of hepatic steatosis due to chronic ethanol consumption. | |
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MedLine Citation:
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PMID: 21765602 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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p59fyn, a protein tyrosine kinase belonging to the src-family, is involved in the regulatory mechanism of acute response to ethanol in the central nervous system. A previous report showed an association between src-family kinase activity and fatty acid oxidation, and it also reported that hepatic free fatty acid levels were low in Fyn-/- mice. We examined, using Fyn-/- mice whether Fyn is also involved in fatty acid metabolism and the development of pathological changes in the liver in response to chronic ethanol consumption. C57BL/6J Fyn-/- and Fyn+/+ mice were fed for 8 weeks with either a liquid diet comprising ethanol or one in which the calories from ethanol were replaced with carbohydrates. Chronic ethanol consumption for 8 weeks resulted in remarkable hepatic steatosis in Fyn+/+ mice but not in Fyn-/- mice. Chronic ethanol consumption induced a significant decrease in hepatic FFA and triglyceride levels in Fyn-/- mice. Levels of interleukin-6, which is associated with the enhancement of fatty acid oxidation, was also increased significantly in the livers of ethanol-fed Fyn-/- mice. The results suggest that Fyn is involved in the enhancement of fatty acid oxidation and the development of hepatic steatosis caused by chronic ethanol consumption. |
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Authors:
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Shinya Fukunishi; Yasuhiro Tsuda; Atsushi Takeshita; Hideo Fukui; Katsuhiko Miyaji; Akira Fukuda; Kazuhide Higuchi |
Publication Detail:
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Type: Journal Article Date: 2011-06-30 |
Journal Detail:
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Title: Journal of clinical biochemistry and nutrition Volume: 49 ISSN: 1880-5086 ISO Abbreviation: J Clin Biochem Nutr Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700907 Medline TA: J Clin Biochem Nutr Country: Japan |
Other Details:
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Languages: eng Pagination: 20-4 Citation Subset: - |
Affiliation:
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Department of Gastroenteroloy and Hepatology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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