| p57 kip2's role beyond Schwann cell cycle control. | |
| | |
MedLine Citation:
|
PMID: 18769142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The p57(kip2) gene encodes a cyclin dependent kinase inhibitor that belongs to the Cip/Kip family of negative cell cycle regulators. Recently, experimental evidence emerged that beyond cell cycle control p57(kip2) also regulates a number of different cellular processes. We found that in Schwann cells, these are the myelinating glial cells of the peripheral nervous system, small hairpin RNA dependent suppression of p57(kip2) results in cell cycle exit and the initiation of the cellular differentiation program. Given that Schwann cells were so far regarded as being unable to differentiate in absence of axons, these were unexpected results. We thus concluded that p57(kip2) is not involved in the control of Schwann cell proliferation but is a main intrinsic negative regulator of Schwann cell differentiation. Here we present GeneChip expression data which reveal the extent and complexity of cell cycle related gene regulations in p57(kip2)-suppressed Schwann cells. In addition, we provide experimental evidence that the differentiation promoting effect is at least partially mediated via p57(kip2)/LIMK-1 interactions. |
| | |
Authors:
|
André Heinen; David Kremer; Hans-Peter Hartung; Patrick Küry |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-09-16 |
Journal Detail:
|
Title: Cell cycle (Georgetown, Tex.) Volume: 7 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-09-19 Completed Date: 2008-11-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
|
Languages: eng Pagination: 2781-6 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Heinrich-Heine-University of Düsseldorf, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Cycle* Cell Differentiation Cyclin-Dependent Kinase Inhibitor p57 / metabolism* Gene Expression Regulation Lim Kinases / metabolism Mice Models, Biological Oligonucleotide Array Sequence Analysis Protein Transport Schwann Cells / cytology*, metabolism Subcellular Fractions / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Cyclin-Dependent Kinase Inhibitor p57; EC 2.7.11.1/Lim Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The yin and yang of the Cdkn2a locus in senescence and aging.
Next Document: ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and...