Document Detail

p57 kip2's role beyond Schwann cell cycle control.
MedLine Citation:
PMID:  18769142     Owner:  NLM     Status:  MEDLINE    
The p57(kip2) gene encodes a cyclin dependent kinase inhibitor that belongs to the Cip/Kip family of negative cell cycle regulators. Recently, experimental evidence emerged that beyond cell cycle control p57(kip2) also regulates a number of different cellular processes. We found that in Schwann cells, these are the myelinating glial cells of the peripheral nervous system, small hairpin RNA dependent suppression of p57(kip2) results in cell cycle exit and the initiation of the cellular differentiation program. Given that Schwann cells were so far regarded as being unable to differentiate in absence of axons, these were unexpected results. We thus concluded that p57(kip2) is not involved in the control of Schwann cell proliferation but is a main intrinsic negative regulator of Schwann cell differentiation. Here we present GeneChip expression data which reveal the extent and complexity of cell cycle related gene regulations in p57(kip2)-suppressed Schwann cells. In addition, we provide experimental evidence that the differentiation promoting effect is at least partially mediated via p57(kip2)/LIMK-1 interactions.
André Heinen; David Kremer; Hans-Peter Hartung; Patrick Küry
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-16
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  7     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-19     Completed Date:  2008-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2781-6     Citation Subset:  IM    
Department of Neurology, Heinrich-Heine-University of Düsseldorf, Germany.
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MeSH Terms
Cell Cycle*
Cell Differentiation
Cyclin-Dependent Kinase Inhibitor p57 / metabolism*
Gene Expression Regulation
Lim Kinases / metabolism
Models, Biological
Oligonucleotide Array Sequence Analysis
Protein Transport
Schwann Cells / cytology*,  metabolism
Subcellular Fractions / metabolism
Reg. No./Substance:
0/Cyclin-Dependent Kinase Inhibitor p57; EC Kinases

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