| The p53 tumor suppressor participates in multiple cell cycle checkpoints. | |
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MedLine Citation:
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PMID: 16741928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The process of cell division is highly ordered and regulated. Checkpoints exist to delay progression into the next cell cycle phase only when the previous step is fully completed. The ultimate goal is to guarantee that the two daughter cells inherit a complete and faithful copy of the genome. Checkpoints can become activated due to DNA damage, exogenous stress signals, defects during the replication of DNA, or failure of chromosomes to attach to the mitotic spindle. Abrogation of cell cycle checkpoints can result in death for a unicellular organism or uncontrolled proliferation and tumorigenesis in metazoans (Nyberg et al., 2002). The tumor suppressor p53 plays a critical role in each of these cell cycle checkpoints and is reviewed here. |
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Authors:
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Luciana E Giono; James J Manfredi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Journal of cellular physiology Volume: 209 ISSN: 0021-9541 ISO Abbreviation: J. Cell. Physiol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-08-28 Completed Date: 2006-10-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 13-20 Citation Subset: IM |
Copyright Information:
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Copyright 2006 Wiley-Liss, Inc. |
Affiliation:
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Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* DNA Repair G1 Phase G2 Phase Genes, cdc* Humans Mice Mitotic Spindle Apparatus / genetics Models, Biological S Phase Signal Transduction Tumor Suppressor Protein p53 / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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CA80058/CA/NCI NIH HHS; CA86001/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Tumor Suppressor Protein p53 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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