Document Detail

p53 suppresses stress-induced cellular senescence via regulation of autophagy under the deprivation of serum.
MedLine Citation:
PMID:  25369834     Owner:  NLM     Status:  Publisher    
The tumor suppressor p53 is widely known for its ability to induce cell cycle arrest or cell death, therefore preventing neoplastic progression. Previous studies have demonstrated novel roles for p53 in the regulation of autophagy and senescence. p53 can not only exert cell cycle‑arresting and senescence‑promoting or suppressing functions, but can also induce autophagic flux, particularly under conditions of nutrient deprivation. The present study demonstrated that p53 was capable of activating autophagy, which permits cell survival under conditions of serum starvation, and suppresses cellular senescence through inhibition of the mammalian target of rapamycin pathway. These results suggest that active autophagy may be a potential mechanism by which p53 suppresses cellular senescence, in response to serum starvation. The findings of the present study provide a potential mechanism for suppression of senescence by p53.
Xinbing Sui; Yong Fang; Haizhou Lou; Kaifeng Wang; Yu Zheng; Fang Lou; Wei Jin; Yinghua Xu; Wei Chen; Hongming Pan; Xian Wang; Weidong Han
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-04
Journal Detail:
Title:  Molecular medicine reports     Volume:  -     ISSN:  1791-3004     ISO Abbreviation:  Mol Med Rep     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-5     Completed Date:  -     Revised Date:  2014-11-6    
Medline Journal Info:
Nlm Unique ID:  101475259     Medline TA:  Mol Med Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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