Document Detail


p53 suppresses stress-induced cellular senescence via regulation of autophagy under the deprivation of serum.
MedLine Citation:
PMID:  25369834     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The tumor suppressor p53 is widely known for its ability to induce cell cycle arrest or cell death, therefore preventing neoplastic progression. Previous studies have demonstrated novel roles for p53 in the regulation of autophagy and senescence. p53 can not only exert cell cycle‑arresting and senescence‑promoting or suppressing functions, but can also induce autophagic flux, particularly under conditions of nutrient deprivation. The present study demonstrated that p53 was capable of activating autophagy, which permits cell survival under conditions of serum starvation, and suppresses cellular senescence through inhibition of the mammalian target of rapamycin pathway. These results suggest that active autophagy may be a potential mechanism by which p53 suppresses cellular senescence, in response to serum starvation. The findings of the present study provide a potential mechanism for suppression of senescence by p53.
Authors:
Xinbing Sui; Yong Fang; Haizhou Lou; Kaifeng Wang; Yu Zheng; Fang Lou; Wei Jin; Yinghua Xu; Wei Chen; Hongming Pan; Xian Wang; Weidong Han
Related Documents :
11781834 - Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human ...
17046024 - Stabilization of telomeres in nonlinear models of proliferating cell lines.
25154664 - Enhanced intracellular translocation and biodistribution of gold nanoparticles function...
11850794 - Analysis of telomerase as a diagnostic biomarker of cervical dysplasia and carcinoma.
11510974 - Colonic endocrine cells in rats with chemically induced colon carcinoma.
18853744 - Degradation of plectin with modulation of cytokeratin 18 in human liver cells during st...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-04
Journal Detail:
Title:  Molecular medicine reports     Volume:  -     ISSN:  1791-3004     ISO Abbreviation:  Mol Med Rep     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-5     Completed Date:  -     Revised Date:  2014-11-6    
Medline Journal Info:
Nlm Unique ID:  101475259     Medline TA:  Mol Med Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Re-building Daniell Cell with a Li-ion exchange Film.
Next Document:  Intracranial Extension of an Orbital Epidermoid Cyst.