| p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment. | |
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MedLine Citation:
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PMID: 21099252 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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p53 as a tumor suppressor protein has been implicated in multiple aspects of biological processes, including apoptosis, cell cycle arrest, senescence, metabolism, differentiation, and angiogenesis. Recently, several studies have shown that p53 can induce autophagy in both transcription-dependent and -independent manners. Nonetheless, p53 may also inhibit autophagy. In addition, p53 participates in homeostatic regulation of energy metabolism, oxidative stress and amino acid metabolism. Although the relationship between autophagy and p53 is quite complicated, and has not been well elucidated, p53 may underlie key aspects of metabolism and cancer biology. Thus, understanding the novel functions of p53 may allow us to develop new anticancer therapeutic approaches. |
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Authors:
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Xinbing Sui; Lijun Jin; Xuefeng Huang; Shumin Geng; Chao He; Xiaotong Hu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-01 |
Journal Detail:
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Title: Autophagy Volume: 7 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Colorectal Surgery; Sir Run Run Shaw Hospital; Zhejiang University; Hangzhou, China. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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