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p53 signaling and autophagy in cancer: A revolutionary strategy could be developed for cancer treatment.
MedLine Citation:
PMID:  21099252     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
p53 as a tumor suppressor protein has been implicated in multiple aspects of biological processes, including apoptosis, cell cycle arrest, senescence, metabolism, differentiation, and angiogenesis. Recently, several studies have shown that p53 can induce autophagy in both transcription-dependent and -independent manners. Nonetheless, p53 may also inhibit autophagy. In addition, p53 participates in homeostatic regulation of energy metabolism, oxidative stress and amino acid metabolism. Although the relationship between autophagy and p53 is quite complicated, and has not been well elucidated, p53 may underlie key aspects of metabolism and cancer biology. Thus, understanding the novel functions of p53 may allow us to develop new anticancer therapeutic approaches.
Authors:
Xinbing Sui; Lijun Jin; Xuefeng Huang; Shumin Geng; Chao He; Xiaotong Hu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-01
Journal Detail:
Title:  Autophagy     Volume:  7     ISSN:  1554-8635     ISO Abbreviation:  Autophagy     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265188     Medline TA:  Autophagy     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Colorectal Surgery; Sir Run Run Shaw Hospital; Zhejiang University; Hangzhou, China.
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