Document Detail


p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver.
MedLine Citation:
PMID:  23300120     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Our results show that p53 plays a role in mitotic fidelity and ploidy resolution in hepatocytes of normal and regenerative liver.
Authors:
Svitlana Kurinna; Sabrina A Stratton; Zeynep Coban; Jill M Schumacher; Markus Grompe; Andrew W Duncan; Michelle Craig Barton
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-02-15
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-23     Completed Date:  2013-07-05     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2004-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / physiology
Cell Proliferation
Hepatectomy
Liver / pathology*,  physiology,  surgery
Liver Regeneration / physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitosis / physiology*
Models, Animal
Ploidies*
Transcription, Genetic / physiology*
Tumor Suppressor Protein p53 / deficiency,  genetics,  physiology*
Grant Support
ID/Acronym/Agency:
P30 CA016672/CA/NCI NIH HHS; R01 DK051592/DK/NIDDK NIH HHS; R01 DK078024/DK/NIDDK NIH HHS; R01-DK078024/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Suppressor Protein p53
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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