Document Detail


p53: its alteration and gallbladder cancer.
MedLine Citation:
PMID:  21131824     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Gallbladder cancer (GBC) is the most common malignancy of the biliary tract. Despite the recent advancements in the understanding of cancer biology the disease still remains a therapeutic challenge with poor survival, and with early surgical resection as the only powerful treatment. Understanding the molecular events in gallbladder carcinogenesis may provide a novel targeted therapeutic approach. Of these, alterations in the tumour suppressor gene, p53, are commonly observed in most human cancers. However, its impact on the pathogenesis of GBC remains obscure. This study attempts to outline the p53 structure, function and its alterations, with special attention to GBC.
Authors:
Rajani Rai; Mallika Tewari; Mohan Kumar; Alok K Singh; Hari S Shukla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)     Volume:  20     ISSN:  1473-5709     ISO Abbreviation:  Eur. J. Cancer Prev.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-01-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300837     Medline TA:  Eur J Cancer Prev     Country:  England    
Other Details:
Languages:  eng     Pagination:  77-85     Citation Subset:  IM    
Affiliation:
aDepartments of Surgical Oncology bPathology, Institute of Medical Sciences cBiochemistry, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
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