| p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. | |
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MedLine Citation:
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PMID: 21353507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The function of p53 induced by ganoderic acids (GAs) in anti-invasion was unknown, although our previous work reported the inhibition of tumor invasion and metastasis by Ganoderic acid T (GA-T). This work indicated that GA-T promoted cell aggregation, inhibited cell adhesion and surpressed cell migration with a dose-dependent manner in human colon tumor cell lines of HCT-116 p53(+/+) and p53(-/-). Furthermore, comparing the ratios of HCT-116 p53(+/+) and p53(-/-) cells, p53 modified GA-T inhibition of migration and adhesion and GA-T promotion of cell aggregation, and p53 also modified GA-T inhibition of NF-κB nuclear translocation, IκBα degradation, and down-regulation of urokinase-type plaminogen activator (uPA), matrix metalloproteinase-2/9 (MMP-2/9), inducible nitric oxide synthase (iNOS/NOS2) protein expression and inducible nitric oxide (NO) production. The results indicated that p53 played an important role in anti-invasion of GA-T in human carcinoma cells. p53 may be an important target for GA-T inhibiting human carcinoma cells anti-invasion. |
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Authors:
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Nian-Hong Chen; Jian-Jiang Zhong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-02-25 |
Journal Detail:
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Title: Phytomedicine : international journal of phytotherapy and phytopharmacology Volume: 18 ISSN: 1618-095X ISO Abbreviation: Phytomedicine Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-07 Completed Date: 2011-10-14 Revised Date: 2011-10-27 |
Medline Journal Info:
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Nlm Unique ID: 9438794 Medline TA: Phytomedicine Country: Germany |
Other Details:
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Languages: eng Pagination: 719-25 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier GmbH. All rights reserved. |
Affiliation:
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State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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pharmacology* Cell Adhesion / drug effects Cell Aggregation / drug effects Cell Line, Tumor Cell Movement / drug effects Colonic Neoplasms / drug therapy*, metabolism, pathology* Drugs, Chinese Herbal / pharmacology HCT116 Cells Humans I-kappa B Proteins / metabolism Lanosterol / analogs & derivatives*, pharmacology Matrix Metalloproteinase 2 / biosynthesis Matrix Metalloproteinase 9 / metabolism Neoplasm Invasiveness Nitric Oxide / metabolism Nitric Oxide Synthase Type II / biosynthesis Phytotherapy Reishi / chemistry Transcription Factor RelA / metabolism Tumor Suppressor Protein p53 / metabolism* Urokinase-Type Plasminogen Activator / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Drugs, Chinese Herbal; 0/I-kappa B Proteins; 0/TP53 protein, human; 0/Transcription Factor RelA; 0/Tumor Suppressor Protein p53; 0/ganoderic acid T; 10102-43-9/Nitric Oxide; 139874-52-5/NF-kappaB inhibitor alpha; 79-63-0/Lanosterol; EC 1.14.13.39/NOS2 protein, human; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 3.4.21.73/Urokinase-Type Plasminogen Activator; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9 |
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