Document Detail


p53 guards the metabolic pathway less travelled.
MedLine Citation:
PMID:  21336302     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Glucose is an important source of energy and carbon, and is required for cell growth. As such, glucose utilization is increased in rapidly dividing cancer cells. The tumour suppressor p53 has now been reported to block a metabolic pathway (the pentose phosphate pathway) that diverts glucose away from bioenergetic into biosynthetic routes.
Authors:
Eyal Gottlieb
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-20
Journal Detail:
Title:  Nature cell biology     Volume:  -     ISSN:  1476-4679     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Cancer Research UK, The Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK. e.gottlieb@beatson.gla.ac.uk.
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